Journal article
The genetic underpinnings of variation in ages at menarche and natural menopause among women from the multi-ethnic Population Architecture using Genomics and Epidemiology (PAGE) Study: A trans-ethnic meta-analysis
PloS one, Vol.13(7), pp.e0200486-e0200486
2018
DOI: 10.1371/journal.pone.0200486
PMCID: PMC6059436
PMID: 30044860
Abstract
Current knowledge of the genetic architecture of key reproductive events across the female life course is largely based on association studies of European descent women. The relevance of known loci for age at menarche (AAM) and age at natural menopause (ANM) in diverse populations remains unclear. We investigated 32 AAM and 14 ANM previously-identified loci and sought to identify novel loci in a trans-ethnic array-wide study of 196,483 SNPs on the MetaboChip (Illumina, Inc.). A total of 45,364 women of diverse ancestries (African, Hispanic/Latina, Asian American and American Indian/Alaskan Native) in the Population Architecture using Genomics and Epidemiology (PAGE) Study were included in cross-sectional analyses of AAM and ANM. Within each study we conducted a linear regression of SNP associations with self-reported or medical record-derived AAM or ANM (in years), adjusting for birth year, population stratification, and center/region, as appropriate, and meta-analyzed results across studies using multiple meta-analytic techniques. For both AAM and ANM, we observed more directionally consistent associations with the previously reported risk alleles than expected by chance (p-valuesbinomial≤0.01). Eight densely genotyped reproductive loci generalized significantly to at least one non-European population. We identified one trans-ethnic array-wide SNP association with AAM and two significant associations with ANM, which have not been described previously. Additionally, we observed evidence of independent secondary signals at three of six AAM trans-ethnic loci. Our findings support the transferability of reproductive trait loci discovered in European women to women of other race/ethnicities and indicate the presence of additional trans-ethnic associations both at both novel and established loci. These findings suggest the benefit of including diverse populations in future studies of the genetic architecture of female growth and development.
Details
- Title: Subtitle
- The genetic underpinnings of variation in ages at menarche and natural menopause among women from the multi-ethnic Population Architecture using Genomics and Epidemiology (PAGE) Study: A trans-ethnic meta-analysis
- Creators
- Lindsay Fernández-Rhodes - Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of AmericaJennifer R Malinowski - Write InSciTe, LLC, Hebron, Connecticut, United States of AmericaYujie Wang - University of North Carolina at Chapel HillRan Tao - Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee, United States of AmericaNathan Pankratz - Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, United States of AmericaJanina M Jeff - Genotyping Arrays Division, Illumina, Inc., San Diego, California, United States of AmericaSachiko Yoneyama - Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of AmericaCara L Carty - Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of AmericaV Wendy Setiawan - Department of Preventive Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of AmericaLoic Le Marchand - Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, United States of AmericaChristopher Haiman - Department of Preventive Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of AmericaSteven Corbett - Kansas Health Institute, Topeka, Kansas, United States of AmericaEllen Demerath - Division of Epidemiology & Community Health, University of Minnesota, Minneapolis, Minnesota, United States of AmericaGerardo Heiss - Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of AmericaMyron Gross - Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, United States of AmericaPetra Buzkova - Department of Biostatistics, School of Public Health, University of Washington, Seattle, Washington, United States of AmericaDana C Crawford - Institute for Computational Biology, Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, United States of AmericaSteven C Hunt - Department of Genetic Medicine, Weill Cornell Medical College in Qatar, Doha, QatarD C Rao - Division of Biostatistics, Washington University in St. Louis, St. Louis, Michigan, United States of AmericaKaren Schwander - Division of Biostatistics, Washington University in St. Louis, St. Louis, Michigan, United States of AmericaAravinda Chakravarti - Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University, Baltimore, Maryland, United States of AmericaOmri Gottesman - Division of General Internal Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States of AmericaNoura S Abul-Husn - The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States of AmericaErwin P Bottinger - The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States of AmericaRuth J F Loos - The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States of AmericaLeslie J Raffel - Division of Genetic and Genomic Medicine, University of California-Irvine, Irvine, California, United States of AmericaJie Yao - Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics at Harbor-UCLA Medical Center, Torrance, California, United States of AmericaXiuqing Guo - Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics at Harbor-UCLA Medical Center, Torrance, California, United States of AmericaSuzette J Bielinski - College of Medicine, Mayo Clinic, Rochester, Minnesota, United States of AmericaJerome I Rotter - Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics at Harbor-UCLA Medical Center, Torrance, California, United States of AmericaDhananjay Vaidya - Department of Medicine, Johns Hopkins University, Baltimore, Maryland, United States of AmericaYii-Der Ida Chen - Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics at Harbor-UCLA Medical Center, Torrance, California, United States of AmericaSheila F Castañeda - South Bay Latino Research Center, Graduate School of Public Health, San Diego State University, San Diego, California, United States of AmericaMartha Daviglus - Institute of Minority Health Research, University of Illinois at Chicago, Chicago, Illinois, United States of AmericaRobert Kaplan - Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York, United States of AmericaGregory A Talavera - South Bay Latino Research Center, Graduate School of Public Health, San Diego State University, San Diego, California, United States of AmericaKelli K Ryckman - Departments of Epidemiology and Pediatrics, University of Iowa, Iowa City, Iowa, United States of AmericaUlrike Peters - Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of AmericaJose Luis Ambite - Information Sciences Institute, University of Southern California, Marina del Rey, California, United States of AmericaSteven Buyske - Department of Genetics, Rutgers University, Piscataway, New Jersey, United States of AmericaLucia Hindorff - Division of Genomic Medicine, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of AmericaCharles Kooperberg - Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of AmericaTara Matise - Department of Genetics, Rutgers University, Piscataway, New Jersey, United States of AmericaNora Franceschini - Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of AmericaKari E North - Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
- Resource Type
- Journal article
- Publication Details
- PloS one, Vol.13(7), pp.e0200486-e0200486
- DOI
- 10.1371/journal.pone.0200486
- PMID
- 30044860
- PMCID
- PMC6059436
- NLM abbreviation
- PLoS One
- ISSN
- 1932-6203
- eISSN
- 1932-6203
- Publisher
- Public Library of Science; United States
- Grant note
- HHSN268201300027C / NHLBI NIH HHS HHSN268200900041C / NHLBI NIH HHS U01 HG004803 / NHGRI NIH HHS HHSN268201100007C / NHLBI NIH HHS U01 HG004402 / NHGRI NIH HHS UL1 TR001881 / NCATS NIH HHS P50 ES015915 / NIEHS NIH HHS UL1 TR000445 / NCATS NIH HHS P30 CA071789 / NCI NIH HHS R01 HL071251 / NHLBI NIH HHS R56 HG010297 / NHGRI NIH HHS HHSN268201100011C / NHLBI NIH HHS ARRA NIH HHS R01 CA063464 / NCI NIH HHS P2C HD050924 / NICHD NIH HHS HHSN268201300025C / NHLBI NIH HHS U01 HG004802 / NHGRI NIH HHS UL1 RR025005 / NCRR NIH HHS HHSN268201100005C / NHLBI NIH HHS HHSN268201100010C / NHLBI NIH HHS R01 DK101855 / NIDDK NIH HHS UL1 RR033176 / NCRR NIH HHS U01 HG007419 / NHGRI NIH HHS U01 HG007416 / NHGRI NIH HHS T32 HL007055 / NHLBI NIH HHS R01 HL071258 / NHLBI NIH HHS UL1 TR000040 / NCATS NIH HHS U01 HG007376 / NHGRI NIH HHS UL1 TR001420 / NCATS NIH HHS R01 HL071250 / NHLBI NIH HHS HHSN268201100012C / NHLBI NIH HHS HHSN263201500003I / NIH HHS R01 HL071051 / NHLBI NIH HHS U01 HG004798 / NHGRI NIH HHS HHSN268201300026C / NHLBI NIH HHS U01 CA136792 / NCI NIH HHS HHSN268201100006C / NHLBI NIH HHS UL1 TR001079 / NCATS NIH HHS U01 HG007417 / NHGRI NIH HHS HHSN268201300029C / NHLBI NIH HHS S10 OD020069 / NIH HHS HHSN268201100008C / NHLBI NIH HHS R01 DK089256 / NIDDK NIH HHS R01 HL071259 / NHLBI NIH HHS R01 HL086694 / NHLBI NIH HHS HHSN268201300028C / NHLBI NIH HHS R01 HL087641 / NHLBI NIH HHS U01 HG004790 / NHGRI NIH HHS R01 HD057194 / NICHD NIH HHS R01 HL071205 / NHLBI NIH HHS HHSN268201100009C / NHLBI NIH HHS U01 HG004801 / NHGRI NIH HHS
- Language
- English
- Date published
- 2018
- Academic Unit
- Stead Family Department of Pediatrics; Epidemiology
- Record Identifier
- 9983996191102771
Metrics
21 Record Views