Journal article
The genetics of age-related macular degeneration
Molecular vision, Vol.5, p.29
11/03/1999
PMID: 10562653
Abstract
Age-related macular degeneration (AMD) is increasingly recognized as a complex genetic disorder in which one or more genes contribute to an individual's susceptibility for developing the condition. Twin and family studies as well as population-based genetic epidemiologic methods have convincingly demonstrated the importance of genetics in AMD, though the extent of heritability, the number of genes involved, and the phenotypic and genetic heterogeneity of the condition remain unresolved. The extent to which other hereditary macular dystrophies such as Stargardts disease, familial radial drusen (malattia leventinese), Best's disease, and peripherin/RDS-related dystrophy are related to AMD remains unclear. Alzheimer's disease, another late onset, heterogeneous degenerative disorder of the central nervous system, offers a valuable model for identifying the issues that confront AMD genetics.
Details
- Title: Subtitle
- The genetics of age-related macular degeneration
- Creators
- Michael B Gorin - The Departments of Ophthalmology and Human Genetics, University of Pittsburgh School of Medicine and Graduate School of Public Health, Pittsburgh, PA 15213, USA. gorin@vision.eei.upmc.eduJohn C S BreitnerPaulus T V M De JongGregory S HagemanCaroline C W KlaverMarkus H KuehnJohanna M Seddon
- Resource Type
- Journal article
- Publication Details
- Molecular vision, Vol.5, p.29
- PMID
- 10562653
- NLM abbreviation
- Mol Vis
- ISSN
- 1090-0535
- eISSN
- 1090-0535
- Publisher
- United States
- Grant note
- EY11515 / NEI NIH HHS R01EY09859 / NEI NIH HHS EY11309 / NEI NIH HHS
- Language
- English
- Date published
- 11/03/1999
- Academic Unit
- Ophthalmology and Visual Sciences
- Record Identifier
- 9983980019702771
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