Journal article
The genomic and immunogenomic landscape of mechanics pathway informs clinical prognosis and response to mechanotherapy
Science China. Life sciences, Vol.67(8), pp.1549-1562
08/01/2024
DOI: 10.1007/s11427-024-2622-1
PMID: 39037695
Abstract
Mechanics shape cell and tissue plasticity and maintain their homeostasis. In cancers, mechanical signals regulate cancer hallmarks via mechanotransduction pathways, such as proliferation, metastasis and metabolic reprogramming. However, comprehensive characterization of mechanotransduction pathway genes and their clinical relevance across different cancer types remains untouched. Herein, we systematically portrayed the alterations of mechanotransduction pathway genes across 31 cancer types using The Cancer Genome Atlas (TCGA) databases. All the cancer types could be categorized into 6 subtypes based upon the transcriptional pattern of mechanics pathway genes. Each subtype has its own unique molecular expression pattern, mutation landscapes, immune infiltrates, and patient clinical outcome. We further found that the responses of two subtypes of cancers, one with the optimal outcome and the other with the worst prognosis, to a classical mechanotherapeutic agent (Fasudil, RhoA/ROCK inhibitor) were totally different, indicating that our cancer stratification system based upon mechanotransduction pathway genes could inform clinical responses of patients to mechanotherapeutic agents. Collectively, our study provides a novel pan-cancer landscape of the mechanotransduction pathways and underscores its potential clinical significance in the prediction of clinical prognosis and therapeutic responses to mechanotherapy among cancer patients.
Details
- Title: Subtitle
- The genomic and immunogenomic landscape of mechanics pathway informs clinical prognosis and response to mechanotherapy
- Creators
- Peidong Zhang - Sichuan UniversityPeiwei Li - Sichuan UniversityMuya Tang - Sichuan UniversityRyan C. Gimple - Washington University in St. LouisLiang Huang - Sichuan UniversityJing Yue - Sichuan UniversityQiuhong Shen - Sichuan UniversityYiwei Du - Sichuan UniversityQian Zhang - Sichuan UniversityZhengnan Yang - Sichuan UniversityHaihuai He - Sichuan UniversityKailin Yang - Cleveland ClinicLinjie Zhao - Sichuan UniversityShengtao Zhou - Sichuan University
- Resource Type
- Journal article
- Publication Details
- Science China. Life sciences, Vol.67(8), pp.1549-1562
- Publisher
- Science Press
- DOI
- 10.1007/s11427-024-2622-1
- PMID
- 39037695
- ISSN
- 1674-7305
- eISSN
- 1869-1889
- Number of pages
- 14
- Grant note
- ASCO2018JS / ASCO Conquer Cancer Foundation 2022ZYD0054; 2019YFH0144 / Sichuan Science-Technology Project 82325039; 82273255; 81822034; 81821002 / National Natural Science Foundation of China; National Natural Science Foundation of China (NSFC) KS021; K1907 / West China Second Hospital, Sichuan University RR2166 / RSNA Research Resident Grant 2022YFA1106600 / National Key Research and Development Program of China; National Key Research & Development Program of China
- Language
- English
- Date published
- 08/01/2024
- Academic Unit
- Radiation Oncology
- Record Identifier
- 9984696573002771
Metrics
5 Record Views