Journal article
The genomics of heart failure: design and rationale of the HERMES consortium
ESC Heart Failure, Vol.8(6), pp.5531-5541
09/03/2021
DOI: 10.1002/ehf2.13517
PMCID: PMC8712846
PMID: 34480422
Abstract
Aims: The HERMES (HEart failure Molecular Epidemiology for Therapeutic targetS) consortium aims to identify the genomic and molecular basis of heart failure.Methods and results: The consortium currently includes 51 studies from 11 countries, including 68 157 heart failure cases and 949 888 controls, with data on heart failure events and prognosis. All studies collected biological samples and performed genome-wide genotyping of common genetic variants. The enrolment of subjects into participating studies ranged from 1948 to the present day, and the median follow-up following heart failure diagnosis ranged from 2 to 116 months. Forty-nine of 51 individual studies enrolled participants of both sexes; in these studies, participants with heart failure were predominantly male (34-90%). The mean age at diagnosis or ascertainment across all studies ranged from 54 to 84 years. Based on the aggregate sample, we estimated 80% power to genetic variant associations with risk of heart failure with an odds ratio of ≥1.10 for common variants (allele frequency ≥ 0.05) and ≥1.20 for low-frequency variants (allele frequency 0.01-0.05) at P < 5 × 10-8 under an additive genetic model.Conclusions: HERMES is a global collaboration aiming to (i) identify the genetic determinants of heart failure; (ii) generate insights into the causal pathways leading to heart failure and enable genetic approaches to target prioritization; and (iii) develop genomic tools for disease stratification and risk prediction.
Details
- Title: Subtitle
- The genomics of heart failure: design and rationale of the HERMES consortium
- Creators
- R Thomas Lumbers - University College LondonSonia Shah - University College LondonHonghuang Lin - Boston UniversityTomasz Czuba - Lund UniversityAlbert Henry - University College LondonDaniel Swerdlow - University College LondonAnders Mälarstig - Karolinska InstituteCharlotte Andersson - Boston UniversityNiek Verweij - University Medical Center GroningenMichael Holmes - National Institute for Health ResearchJohan Ärnlöv - Karolinska InstituteHarry Hemingway - National Institute for Health ResearchNeneh Sallah - University College LondonPeter Almgren - Lund UniversityKrishna Aragam - Broad InstituteGeraldine Asselin - Montreal Heart InstituteJoshua Backman - Regeneron Genetics Center, 777 Old Saw Mill River Road, TarrytownMary Biggs - University of WashingtonHeather Bloom - Emory UniversityEric Boersma - Erasmus University RotterdamJeffrey Brandimarto - University of PennsylvaniaMichael Brown - The University of Texas Health Science Center at HoustonHans-Peter Brunner-La Rocca - Maastricht University Medical CentreDavid Carey - Department of Molecular and Functional Genomics, Geisinger, Danville, PAMark Chaffin - Broad InstituteDaniel Chasman - Harvard UniversityOlympe Chazara - AstraZenecaXing Chen - Pfizer (Switzerland)Xu Chen - Karolinska InstituteJonathan Chung - Regeneron Genetics Center, 777 Old Saw Mill River Road, TarrytownWilliam Chutkow - NovartisJohn Cleland - University of GlasgowJames Cook - University of LiverpoolSimon de Denus - University of MontrealAbbas Dehghan - Imperial College LondonGraciela Delgado - Heidelberg UniversitySpiros Denaxas - University College of London [London]Alexander Doney - University of DundeeMarcus Dörr - Greifswald University HospitalSamuel Dudley - University of MinnesotaGunnar Engström - Lund UniversityTõnu Esko - University of TartuGhazaleh Fatemifar - University College LondonStephan Felix - Greifswald University HospitalChris Finan - University College LondonIan Ford - Robertson Centre for BiostatisticsFrancoise Fougerousse - Institut de Recherches Internationales Servier [Suresnes]René Fouodjio - Montreal Heart InstituteMohsen Ghanbari - Erasmus MCSahar Ghasemi - Greifswald University HospitalVilmantas Giedraitis - Uppsala UniversityFranco Giulianini - Brigham and Women's HospitalJohn Gottdiener - University of Maryland, BaltimoreStefan Gross - Greifswald University HospitalDaníel Guðbjartsson - University of IcelandHongsheng Gui - Henry Ford HospitalRebecca Gutmann - Roy J. and Lucille A. Carver College of MedicineChristopher Haggerty - Geisinger Autism & Developmental Medicine Institute [Danville, PA, USA]Pim van der Harst - University Medical Center GroningenÅsa Hedman - Karolinska InstituteAnna Helgadottir - AmgenHans Hillege - University Medical Center GroningenCraig Hyde - PfizerJaison Jacob - Novartis (India)J Wouter Jukema - Leiden University Medical Center (LUMC)Frederick Kamanu - Broad InstituteIsabella Kardys - Erasmus University RotterdamMaryam Kavousi - Erasmus MCKay-Tee Khaw - University of CambridgeMarcus Kleber - Heidelberg UniversityLars Køber - Copenhagen University HospitalAndrea Koekemoer - University of LeicesterBill Kraus - Durham UniversityKaroline Kuchenbaecker - University College LondonClaudia Langenberg - University of CambridgeLars Lind - Uppsala UniversityCecilia Lindgren - University of OxfordBarry London - University of IowaLuca Lotta - University of CambridgeRuth Lovering - University College LondonJian'An Luan - University of CambridgePatrik Magnusson - Karolinska Institutet [Stockholm]Anubha Mahajan - GenentechDouglas Mann - Washington University in St. LouisKenneth Margulies - University of PennsylvaniaNicholas Marston - Brigham and Women's HospitalWinfried März - Medical University of GrazJohn Mcmurray - University of GlasgowOlle Melander - Lund UniversityGiorgio Melloni - Broad Institute of MIT and HarvardIfy Mordi - University of DundeeMichael Morley - University of PennsylvaniaAndrew Morris - University of EdinburghAlanna Morrison - The University of Texas Health Science Center at HoustonMichael Nagle - PfizerChristopher Nelson - University of LeicesterChristopher Newton-Cheh - Harvard UniversityAlexander Niessner - Medical University of ViennaTeemu Niiranen - University of TurkuChristoph Nowak - Karolinska Institutet [Stockholm]Regeneron Genetics Center
- Resource Type
- Journal article
- Publication Details
- ESC Heart Failure, Vol.8(6), pp.5531-5541
- DOI
- 10.1002/ehf2.13517
- PMID
- 34480422
- PMCID
- PMC8712846
- NLM abbreviation
- ESC Heart Fail
- ISSN
- 2055-5822
- eISSN
- 2055-5822
- Publisher
- Wiley
- Grant note
- DOI: 10.13039/501100001729, name: Stiftelsen för Strategisk Forskning, award: IRC15‐0067; DOI: 10.13039/501100004063, name: Knut och Alice Wallenbergs Stiftelse; DOI: 10.13039/501100011077, name: Skånes universitetssjukhus; DOI: 10.13039/501100003173, name: Crafoordska Stiftelsen; DOI: 10.13039/501100000781, name: European Research Council, award: ERC‐STG‐2015‐679242; DOI: 10.13039/501100004359, name: Vetenskapsrådet, award: 2009‐1039, 349‐2006‐237, 2017‐02554; DOI: 10.13039/501100003793, name: Hjärt-Lungfonden, award: 2019‐0526, 2016‐0315, 2016‐0134; DOI: 10.13039/100008748, name: Department of Orthopaedic Surgery, Boston University School of Medicine; DOI: 10.13039/100015927, name: Evans Medical Foundation; DOI: 10.13039/100016873, name: Framingham Heart Study, award: 75N92019D00031, HHSN268201500001I, NO1‐HC‐25195; DOI: 10.13039/100000968, name: American Heart Association, award: 18SFRN34250007; DOI: 10.13039/100000050, name: National Heart, Lung, and Blood Institute; DOI: 10.13039/100006108, name: National Center for Advancing Translational Sciences, award: UL1TR001881; DOI: 10.13039/100000002, name: National Institutes of Health, award: 1R01HL139731, U10 HL110337, U10 HL110336, U10 HL110302, U10 HL110312, U10 HL110338, U10 HL110262, U10 HL110309, U10 HL110342, U10 HL110297, U10 HL084904; DOI: 10.13039/501100012317, name: UCLH Biomedical Research Centre
- Language
- English
- Date published
- 09/03/2021
- Academic Unit
- Molecular Physiology and Biophysics; Cardiovascular Medicine; Internal Medicine
- Record Identifier
- 9984297504702771
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