Journal article
The granuloma in cryptococcal disease
PLoS pathogens, Vol.17(3), pp.e1009342-e1009342
03/18/2021
DOI: 10.1371/journal.ppat.1009342
PMCID: PMC7971563
PMID: 33735307
Abstract
Although we have recognized cryptococcosis as a disease entity for well over 100 years, there are many details about its pathogenesis which remain unknown. A major barrier to better understanding is the very broad range of clinical and pathological forms cryptococcal infections can take. One such form has been historically called the cryptococcal granuloma, or the cryptococcoma. These words have been used to describe essentially any mass lesion associated with infection, due to their presumed similarity to the quintessential granuloma, the tubercle in tuberculosis. Although clear distinctions between tuberculosis and cryptococcal disease have been discovered, cellular and molecular studies still confirm some important parallels between these 2 diseases and what we now call granulomatous inflammation. In this review, we shall sketch out some of the history behind the term "granuloma" as it pertains to cryptococcal disease, explore our current understanding of the biology of granuloma formation, and try to place that understanding in the context of the myriad pathological presentations of this infection. Finally, we shall summarize the role of the granuloma in cryptococcal latency and present opportunities for future investigations.
Details
- Title: Subtitle
- The granuloma in cryptococcal disease
- Creators
- Laura C Ristow - University of IowaJ Muse Davis - Stead Family Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, Iowa, United States of America
- Resource Type
- Journal article
- Publication Details
- PLoS pathogens, Vol.17(3), pp.e1009342-e1009342
- DOI
- 10.1371/journal.ppat.1009342
- PMID
- 33735307
- PMCID
- PMC7971563
- NLM abbreviation
- PLoS Pathog
- ISSN
- 1553-7366
- eISSN
- 1553-7374
- Grant note
- DOI: 10.13039/100000002, name: National Institutes of Health, award: 7K08AI132720; DOI: 10.13039/100000002, name: National Institutes of Health, award: 1R01AI147541
- Language
- English
- Date published
- 03/18/2021
- Academic Unit
- Stead Family Department of Pediatrics; Infectious Disease (Pediatrics)
- Record Identifier
- 9984384343002771
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