Journal article
The great masquerader of malignancy: chronic intestinal pseudo-obstruction
Biomarker research, Vol.2(1), p.23
12/05/2014
DOI: 10.1186/s40364-014-0023-y
PMCID: PMC4310203
PMID: 25635225
Abstract
Paraneoplastic syndromes can precede the initial manifestation and diagnosis of cancer. Paraneoplastic syndromes are a heterogeneous group of disorders caused by mechanisms other than the local presence of tumor cells. These phenomena are mediated by humoral factors secreted by tumor cells or by tumor mediated immune responses. Among paraneoplastic syndromes, chronic intestinal pseudo-obstruction (CIPO) is rare and represents a particularly difficult clinical challenge. Paraneoplastic CIPO is a highly morbid syndrome characterized by impaired gastrointestinal propulsion with symptoms and signs of mechanical bowel obstruction. Clinical outcomes of paraneoplastic CIPO are often deleterious. The current standard of care for the management of CIPO includes supportive treatment with promotility and anti-secretory agents. However, the majority of patients with CIPO eventually require the resection of the non-functioning gut segment. Here, we present a 62-year-old patient with anti-Hu antibody associated paraneoplastic CIPO and underlying small cell lung cancer who underwent treatment with cisplatin and etoposide. Herein, we discuss diagnosis, prognosis, proposed mechanisms, treatment options, and future potential therapeutic strategies of paraneoplastic CIPO.
Details
- Title: Subtitle
- The great masquerader of malignancy: chronic intestinal pseudo-obstruction
- Creators
- Josephine A Taverna - Division of Hematology-Oncology, Department of Medicine, Southern Arizona VA Health Care System, 3601 S 6Th Ave, Tucson, AZ 85723 USA Division of Hematology-Oncology, Department of Medicine, University of Arizona Cancer Center, 1515 N Campbell Ave, Tucson, AZ 85724 USA University of Arizona College of Medicine, 1501 N. Campbell Ave, Tucson, AZ 85724 USA Department of Medicine, University of Arizona College of Medicine, 1501 N. Campbell Ave, Rm 6336, Tucson, AZ 85724 USAHani M Babiker - Division of Hematology-Oncology, Department of Medicine, Southern Arizona VA Health Care System, 3601 S 6Th Ave, Tucson, AZ 85723 USA Division of Hematology-Oncology, Department of Medicine, University of Arizona Cancer Center, 1515 N Campbell Ave, Tucson, AZ 85724 USA University of Arizona College of Medicine, 1501 N. Campbell Ave, Tucson, AZ 85724 USA Department of Medicine, University of Arizona College of Medicine, 1501 N. Campbell Ave, Rm 6336, Tucson, AZ 85724 USASeongseok Yun - University of Arizona Cancer CenterMaria C Bishop - Division of Hematology-Oncology, Department of Medicine, Southern Arizona VA Health Care System, 3601 S 6Th Ave, Tucson, AZ 85723 USA Division of Hematology-Oncology, Department of Medicine, University of Arizona Cancer Center, 1515 N Campbell Ave, Tucson, AZ 85724 USA University of Arizona College of Medicine, 1501 N. Campbell Ave, Tucson, AZ 85724 USA Department of Medicine, University of Arizona College of Medicine, 1501 N. Campbell Ave, Rm 6336, Tucson, AZ 85724 USASarah Lau-Braunhut - University of ArizonaPaul N Meyer - Southern Arizona VA Health Care SystemThomas Enzler - Division of Hematology-Oncology, Department of Medicine, Southern Arizona VA Health Care System, 3601 S 6Th Ave, Tucson, AZ 85723 USA Division of Hematology-Oncology, Department of Medicine, University of Arizona Cancer Center, 1515 N Campbell Ave, Tucson, AZ 85724 USA University of Arizona College of Medicine, 1501 N. Campbell Ave, Tucson, AZ 85724 USA Department of Medicine, University of Arizona College of Medicine, 1501 N. Campbell Ave, Rm 6336, Tucson, AZ 85724 USA
- Resource Type
- Journal article
- Publication Details
- Biomarker research, Vol.2(1), p.23
- DOI
- 10.1186/s40364-014-0023-y
- PMID
- 25635225
- PMCID
- PMC4310203
- NLM abbreviation
- Biomark Res
- ISSN
- 2050-7771
- eISSN
- 2050-7771
- Publisher
- BioMed Central
- Language
- English
- Date published
- 12/05/2014
- Academic Unit
- Pathology
- Record Identifier
- 9984822989002771
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