Journal article
The gut microbiota and gastrointestinal surgery
Nature reviews. Gastroenterology & hepatology, Vol.14(1), pp.43-54
01/01/2017
DOI: 10.1038/nrgastro.2016.139
PMID: 27729657
Abstract
Surgery involving the gastrointestinal. tract continues to prove challenging because of the persistence of unpredictable complications such as anastomotic leakage and life-threatening infections. Removal of diseased intestinal segments results in substantial catabolic stress and might require complex reconstructive surgery to maintain the functional continuity of the intestinal tract. As gastrointestinal surgery necessarily involves a breach of an epithelial barrier colonized by microorganisms, preoperative intestinal antisepsis is used to reduce infection-related complications. The current approach to intestinal antisepsis varies widely across institutions and countries with little understanding of its mechanism of action, effect on the gut microbiota and overall efficacy. Many of the current approaches to intestinal antisepsis before gastrointestinal surgery run counterto emerging concepts of intestinal microbiota contributing to immune function and recovery from injury. Here, we review evidence outlining the role of gut microbiota in recovery from gastrointestinal surgery, particularly in the development of infections and anastomotic leak. To make surgery safer and further reduce complications, a molecular, genetic and functional understanding of the response of the gastrointestinal tract to alterations in its microbiota is needed. Methods can then be developed to preserve the health-promoting functions of the microbiota while at the same time suppressing their harmful effects.
Details
- Title: Subtitle
- The gut microbiota and gastrointestinal surgery
- Creators
- Kristina Guyton - University of ChicagoJohn C. Alverdy - University of Chicago
- Resource Type
- Journal article
- Publication Details
- Nature reviews. Gastroenterology & hepatology, Vol.14(1), pp.43-54
- Publisher
- Springer Nature
- DOI
- 10.1038/nrgastro.2016.139
- PMID
- 27729657
- ISSN
- 1759-5045
- eISSN
- 1759-5053
- Number of pages
- 12
- Language
- English
- Date published
- 01/01/2017
- Academic Unit
- Surgery
- Record Identifier
- 9984322948102771
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