The hearing hippocampus

Alexander J Billig; Meher Lad; William Sedley; Timothy D Griffiths

doi:10.1016/j.pneurobio.2022.102326

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Journal article

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The hearing hippocampus

Alexander J Billig, Meher Lad, William Sedley and Timothy D Griffiths

Progress in neurobiology, Vol.218, pp.102326-102326

11/2022

DOI: 10.1016/j.pneurobio.2022.102326

PMCID: PMC10510040

PMID: 35870677

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Abstract

The hippocampus has a well-established role in spatial and episodic memory but a broader function has been proposed including aspects of perception and relational processing. Neural bases of sound analysis have been described in the pathway to auditory cortex, but wider networks supporting auditory cognition are still being established. We review what is known about the role of the hippocampus in processing auditory information, and how the hippocampus itself is shaped by sound. In examining imaging, recording, and lesion studies in species from rodents to humans, we uncover a hierarchy of hippocampal responses to sound including during passive exposure, active listening, and the learning of associations between sounds and other stimuli. We describe how the hippocampus' connectivity and computational architecture allow it to track and manipulate auditory information - whether in the form of speech, music, or environmental, emotional, or phantom sounds. Functional and structural correlates of auditory experience are also identified. The extent of auditory-hippocampal interactions is consistent with the view that the hippocampus makes broad contributions to perception and cognition, beyond spatial and episodic memory. More deeply understanding these interactions may unlock applications including entraining hippocampal rhythms to support cognition, and intervening in links between hearing loss and dementia.

Auditory Cortex

Auditory Perception - physiology

Cognition

Hearing

Hippocampus - physiology

Humans

Learning - physiology

Details

Title: Subtitle: The hearing hippocampus
Creators: Alexander J Billig - University College London
Meher Lad - Newcastle University
William Sedley - Newcastle University
Timothy D Griffiths - Newcastle University
Resource Type: Journal article
Publication Details: Progress in neurobiology, Vol.218, pp.102326-102326
DOI: 10.1016/j.pneurobio.2022.102326
PMID: 35870677
PMCID: PMC10510040
ISSN: 0301-0082
eISSN: 1873-5118
Grant note: WT106964MA / Wellcome Trust MR/V006568/1 / Medical Research Council MR/T032553/1 / Medical Research Council
Language: English
Date published: 11/2022
Academic Unit: Psychological and Brain Sciences
Record Identifier: 9984627331702771

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