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The heart in diabetes mellitus. Part I. Biochemical basis for myocardial dysfunction
Journal article   Open access   Peer reviewed

The heart in diabetes mellitus. Part I. Biochemical basis for myocardial dysfunction

L. H. Opie, M. J. Tansey and B. M. Kennelly
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, Vol.56(6), pp.207-210
1979
url
https://hdl.handle.net/10520/AJA20785135_15428View
Published (Version of record) Open Access

Abstract

The heart in acutely diabetic animals is subject to multiple inhibitions of glucose metabolism caused by enhanced metabolism of free fatty acids (FFA) and ketone bodies. Such metabolic changes may impair the reaction of the diabetic heart to oxygen lack. In chronically diabetic hearts the increased deposition of triglycerides in the heart and the formation of glycoproteins may underlie the newly recognized clinical entity of diabetic cardiomyopathy.

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35 Times Cited - Web of Science
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