Journal article
The heritability of metabolic profiles in newborn twins
Heredity, Vol.110(3), pp.253-258
03/2013
DOI: 10.1038/hdy.2012.75
PMCID: PMC3668651
PMID: 23149456
Abstract
Identifying genetic and metabolic biomarkers in neonates has the potential to improve diagnosis and treatment of common complex neonatal diseases, and potentially lead to risk assessment and preventative measures for common adulthood illnesses such as diabetes and cardiovascular disease. There is a wealth of information on using fatty acid, amino acid and organic acid metabolite profiles to identify rare inherited congenital diseases through newborn screening, but little is known about these metabolic profiles in the context of the 'healthy' newborn. Recent studies have implicated many of the amino acid and fatty acid metabolites utilized in newborn screening in common complex adult diseases such as cardiovascular disease, insulin resistance and obesity. To determine the heritability of metabolic profiles in newborns, we examined 381 twin pairs obtained from the Iowa Neonatal Metabolic Screening Program. Heritability was estimated using multilevel mixed-effects linear regression adjusting for gestational age, gender, weight and age at time of sample collection. The highest heritability was for short-chain acylcarnitines, specifically C4 (h²=0.66, P=2 × 10⁻¹⁶), C4-DC (h²=0.83, P<10⁻¹⁶) and C5 (h²=0.61, P=1 × 10⁻⁹). Thyroid stimulating hormone (h²=0.58, P=2 × 10⁻⁵) and immunoreactive trypsinogen (h²=0.52, P=3 × 10⁻⁹) also have a strong genetic component. This is direct evidence for a strong genetic contribution to the metabolic profile at birth and that newborn screening data can be utilized for studying the genetic regulation of many clinically relevant metabolites.
Details
- Title: Subtitle
- The heritability of metabolic profiles in newborn twins
- Creators
- F Y Alul - Department of Pediatrics, University of Iowa Hospitals and Clinics, Iowa City, IA, USAD E CookO A ShchelochkovL G FleenerS L BerberichJ C MurrayK K Ryckman
- Resource Type
- Journal article
- Publication Details
- Heredity, Vol.110(3), pp.253-258
- DOI
- 10.1038/hdy.2012.75
- PMID
- 23149456
- PMCID
- PMC3668651
- NLM abbreviation
- Heredity (Edinb)
- ISSN
- 0018-067X
- eISSN
- 1365-2540
- Publisher
- England
- Grant note
- P30 ES005605 / NIEHS NIH HHS R01 HD052953 / NICHD NIH HHS R01 HD-52953 / NICHD NIH HHS R00 HD065786 / NICHD NIH HHS K99 HD065786 / NICHD NIH HHS R01 HD057192 / NICHD NIH HHS R01 HD-57192 / NICHD NIH HHS K99 HD-65786 / NICHD NIH HHS
- Language
- English
- Date published
- 03/2013
- Academic Unit
- Anatomy and Cell Biology; International Programs; Stead Family Department of Pediatrics; Epidemiology; Pediatric Dentistry; Craniofacial Anomalies Research Center; Nursing; Public Policy Center (Archive); Dental Research
- Record Identifier
- 9983995000802771
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