Journal article
The histology of brain tumors for 67 331 children and 671 085 adults diagnosed in 60 countries during 2000-2014: a global, population-based study (CONCORD-3)
Neuro-oncology (Charlottesville, Va.), Vol.23(10), pp.1765-1776
10/01/2021
DOI: 10.1093/neuonc/noab067
PMCID: PMC8485444
PMID: 33738488
Abstract
Abstract
Background
Global variations in survival for brain tumors are very wide when all histological types are considered together. Appraisal of international differences should be informed by the distribution of histology, but little is known beyond Europe and North America.
Methods
The source for the analysis was the CONCORD database, a program of global surveillance of cancer survival trends, which includes the tumor records of individual patients from more than 300 population-based cancer registries. We considered all patients aged 0-99 years who were diagnosed with a primary brain tumor during 2000-2014, whether malignant or nonmalignant. We presented the histology distribution of these tumors, for patients diagnosed during 2000-2004, 2005-2009, and 2010-2014.
Results
Records were submitted from 60 countries on 5 continents, 67 331 for children and 671 085 for adults. After exclusion of irrelevant morphology codes, the final study population comprised 60 783 children and 602 112 adults. Only 59 of 60 countries covered in CONCORD-3 were included because none of the Mexican records were eligible. We defined 12 histology groups for children, and 11 for adults. In children (0-14 years), the proportion of low-grade astrocytomas ranged between 6% and 50%. Medulloblastoma was the most common subtype in countries where low-grade astrocytoma was less commonly reported. In adults (15-99 years), the proportion of glioblastomas varied between 9% and 69%. International comparisons were made difficult by wide differences in the proportion of tumors with unspecified histology, which accounted for up to 52% of diagnoses in children and up to 65% in adults.
Conclusions
To our knowledge, this is the first account of the global histology distribution of brain tumors, in children and adults. Our findings provide insights into the practices and the quality of cancer registration worldwide.
Details
- Title: Subtitle
- The histology of brain tumors for 67 331 children and 671 085 adults diagnosed in 60 countries during 2000-2014: a global, population-based study (CONCORD-3)
- Creators
- Fabio Girardi - Cancer Survival Group, London School of Hygiene and Tropical Medicine, London, UKBrian Rous - National Cancer Registration and Analysis Service, Public Health England, London, UKGemma Gatta - Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, ItalyNaomi Fersht - Cancer Division, University College London Hospitals NHS Foundation Trust, London, UKHans H Storm - Danish Cancer Society, Copenhagen, DenmarkJessica R Rodrigues - Registo Oncológico Regional do Norte, Porto, PortugalChristian Herrmann - Cancer Registry of St Gallen-Appenzell, St Gallen, SwitzerlandRafael Marcos-Gragera - Epidemiology Unit and Girona Cancer Registry, Girona, SpainRafael Peris-Bonet - Registro Español de Tumores Infantiles, Valencia, SpainMikhail Valkov - Arkhangelsk Regional Cancer Registry, Arkhangelsk, Russian FederationHannah K Weir - Centers for Disease Control and Prevention, Atlanta, Georgia, USARyan R Woods - British Columbia Cancer Registry, Vancouver, British Columbia, CanadaHui You - New South Wales Cancer Registry, Alexandria, AustraliaPatricia A Cueva - Quito Cancer Registry, Quito, EcuadorPrithwish De - Ontario Cancer Registry, Toronto, Ontario, CanadaVeronica Di Carlo - Cancer Survival Group, London School of Hygiene and Tropical Medicine, London, UKTom Børge Johannesen - The Cancer Registry of Norway, Oslo, NorwayCarlos A Lima - Registro de Câncer de Base Populacional de Aracaju, Aracaju, BrazilCharles F Lynch - State Health Registry of Iowa, Iowa City, Iowa, USAMichel P Coleman - Cancer Survival Group, London School of Hygiene and Tropical Medicine, London, UKClaudia Allemani - Cancer Survival Group, London School of Hygiene and Tropical Medicine, London, UKCONCORD Working Group
- Resource Type
- Journal article
- Publication Details
- Neuro-oncology (Charlottesville, Va.), Vol.23(10), pp.1765-1776
- Publisher
- Oxford University Press
- DOI
- 10.1093/neuonc/noab067
- PMID
- 33738488
- PMCID
- PMC8485444
- ISSN
- 1522-8517
- eISSN
- 1523-5866
- Grant note
- DOI: 10.13039/501100001273, name: Children with Cancer UK
- Language
- English
- Date published
- 10/01/2021
- Academic Unit
- Epidemiology
- Record Identifier
- 9984214790302771
Metrics
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