Journal article
The histology of ovarian cancer: worldwide distribution and implications for international survival comparisons (CONCORD-2)
Gynecologic oncology, Vol.144(2), pp.405-413
02/2017
DOI: 10.1016/j.ygyno.2016.10.019
PMCID: PMC6195192
PMID: 27931752
Abstract
Ovarian cancers comprise several histologically distinct tumour groups with widely different prognosis. We aimed to describe the worldwide distribution of ovarian cancer histology and to understand what role this may play in international variation in survival.
The CONCORD programme is the largest population-based study of global trends in cancer survival. Data on 681,759 women diagnosed during 1995-2009 with cancer of the ovary, fallopian tube, peritoneum and retroperitonum in 51 countries were included. We categorised ovarian tumours into six histological groups, and explored the worldwide distribution of histology.
During 2005-2009, type II epithelial tumours were the most common. The proportion was much higher in Oceania (73.1%), North America (73.0%) and Europe (72.6%) than in Central and South America (65.7%) and Asia (56.1%). By contrast, type I epithelial tumours were more common in Asia (32.5%), compared with only 19.4% in North America. From 1995 to 2009, the proportion of type II epithelial tumours increased from 68.6% to 71.1%, while the proportion of type I epithelial tumours fell from 23.8% to 21.2%. The proportions of germ cell tumours, sex cord-stromal tumours, other specific non-epithelial tumours and tumours of non-specific morphology all remained stable over time.
The distribution of ovarian cancer histology varies widely worldwide. Type I epithelial, germ cell and sex cord-stromal tumours are generally associated with higher survival than type II tumours, so the proportion of these tumours may influence survival estimates for all ovarian cancers combined. The distribution of histological groups should be considered when comparing survival between countries and regions.
Details
- Title: Subtitle
- The histology of ovarian cancer: worldwide distribution and implications for international survival comparisons (CONCORD-2)
- Creators
- Melissa Matz - Cancer Survival Group, London School of Hygiene & Tropical Medicine, London, UK. Electronic address: Melissa.Matz@LSHTM.ac.ukMichel P Coleman - Cancer Survival Group, London School of Hygiene & Tropical Medicine, London, UKMilena Sant - Department of Preventive and Predictive Medicine, Analytical Epidemiology and Health Impact Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, ItalyMaria Dolores Chirlaque - Department of Epidemiology, Regional Health Council, IMIB, Arrixaca, Murcia, Spain, CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain, Department of Health and Social Sciences, Murcia University, Murcia, SpainOtto Visser - Department of Registration, Netherlands Comprehensive Cancer Organisation, Utrecht, The NetherlandsMartin Gore - The Royal Marsden NHS Foundation Trust, London, UKClaudia Allemani - Cancer Survival Group, London School of Hygiene & Tropical Medicine, London, UKCONCORD Working Group
- Contributors
- C. F Lynch (Contributor) - University of Iowa, Epidemiology
- Resource Type
- Journal article
- Publication Details
- Gynecologic oncology, Vol.144(2), pp.405-413
- DOI
- 10.1016/j.ygyno.2016.10.019
- PMID
- 27931752
- PMCID
- PMC6195192
- NLM abbreviation
- Gynecol Oncol
- ISSN
- 0090-8258
- eISSN
- 1095-6859
- Grant note
- name: Canadian Partnership Against Cancer; DOI: 10.13039/100013668, name: Cancer Focus Northern Ireland; DOI: 10.13039/501100001171, name: Cancer Institute New South Wales; DOI: 10.13039/501100000289, name: Cancer Research UK, award: C1336, A16148; DOI: 10.13039/100000030, name: US Centers for Disease Control and Prevention, award: 12FED03123, ACO12036; DOI: 10.13039/501100006505, name: Swiss Re; name: Swiss Cancer Research Foundation; name: Swiss Cancer League; DOI: 10.13039/100007472, name: University of Kentucky, award: 3049024672-12-568
- Language
- English
- Date published
- 02/2017
- Academic Unit
- Epidemiology
- Record Identifier
- 9984214842302771
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