Journal article
The home air in agriculture pediatric intervention (HAPI) trial: Rationale and methods
Contemporary clinical trials, Vol.96, pp.106085-106085
09/2020
DOI: 10.1016/j.cct.2020.106085
PMID: 32721578
Abstract
Data addressing air quality effects on children with asthma in rural U.S. communities are rare. Our community engaged research partnership previously demonstrated associations between neighborhood NH3 and ambient PM2.5 and asthma in the agricultural lower Yakima Valley of Washington. As a next step, the partnership desired an intervention approach to address concerns about pediatric asthma in this largely Latino immigrant, farm worker community.
The Home Air in Agriculture Pediatric Intervention (HAPI) sought to examine the effectiveness of enrichment of an existing asthma education program with portable high-efficiency particulate air (HEPA) cleaners designed to reduce PM2.5 and NH3. We investigated the effect of this enriched approach on these exposures and asthma health measures.
We randomized children with poorly controlled asthma to a control arm (current asthma education program) or an intervention arm (current asthma education program + placement of two indoor air cleaners in the family's home). Outcomes included (1) 14-day integrated samples of indoor air contaminants (PM2.5 and NH3) at baseline and one-year follow-up and (2) child asthma health metrics at baseline, midpoint (4–6 months) and one-year follow-up. These included the Asthma Control Test, symptoms days, clinical utilization, oral corticosteroid use, pulmonary function, fractional exhaled nitric oxide, and urinary leukotriene E4 concentration.
To our knowledge, this is the first randomized HEPA cleaner intervention designed to assess NH3 as well as PM2.5 and to evaluate health outcomes of children with asthma in an agricultural region.
Details
- Title: Subtitle
- The home air in agriculture pediatric intervention (HAPI) trial: Rationale and methods
- Creators
- Erin E Masterson - Department of Environmental & Occupational Health Sciences, University of Washington, Seattle, WA, United States of AmericaLisa B Younglove - Department of Environmental & Occupational Health Sciences, University of Washington, Seattle, WA, United States of AmericaAdriana Perez - Yakima Valley Farm Worker's Clinic, Toppenish, WA, United States of AmericaElizabeth Torres - Northwest Communities Education Center, Radio KDNA, Granger, WA, United States of AmericaJennifer E Krenz - Department of Environmental & Occupational Health Sciences, University of Washington, Seattle, WA, United States of AmericaMaria I Tchong French - Department of Environmental & Occupational Health Sciences, University of Washington, Seattle, WA, United States of AmericaAnne M Riederer - Department of Environmental & Occupational Health Sciences, University of Washington, Seattle, WA, United States of AmericaPaul D Sampson - Department of Statistics, University of Washington, Seattle, WA, United States of AmericaNervana Metwali - Department of Occupational and Environmental Health, University of Iowa, Iowa City, IA, United States of AmericaEsther Min - Department of Environmental & Occupational Health Sciences, University of Washington, Seattle, WA, United States of AmericaKaren L Jansen - Department of Environmental & Occupational Health Sciences, University of Washington, Seattle, WA, United States of AmericaGino Aisenberg - School of Social Work, University of Washington, Seattle, WA, United States of AmericaRyan S Babadi - Department of Environmental & Occupational Health Sciences, University of Washington, Seattle, WA, United States of AmericaStephanie A Farquhar - Department of Environmental & Occupational Health Sciences, University of Washington, Seattle, WA, United States of AmericaPeter S Thorne - Department of Occupational and Environmental Health, University of Iowa, Iowa City, IA, United States of AmericaCatherine J Karr - Department of Environmental & Occupational Health Sciences, University of Washington, Seattle, WA, United States of America
- Resource Type
- Journal article
- Publication Details
- Contemporary clinical trials, Vol.96, pp.106085-106085
- DOI
- 10.1016/j.cct.2020.106085
- PMID
- 32721578
- NLM abbreviation
- Contemp Clin Trials
- ISSN
- 1551-7144
- eISSN
- 1559-2030
- Publisher
- Elsevier Inc
- Grant note
- DOI: 10.13039/100000066, name: NIEHS, award: 5R01ES023510; DOI: 10.13039/100000066, name: NIEHS, award: P30ES007033, U2CES026561; DOI: 10.13039/100000066, name: NIEHS; DOI: 10.13039/100000066, name: National Institutes of Environmental Health Sciences; name: Environmental Public Health Program; name: Northwest Communities Education Center
- Language
- English
- Date published
- 09/2020
- Academic Unit
- Civil and Environmental Engineering; Occupational and Environmental Health
- Record Identifier
- 9984001085702771
Metrics
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