Journal article
The hospitalization rate and clinical characteristics of mucormycosis prior and during COVID-19 pandemic: A single-center study
Journal of infection in developing countries, Vol.17(6), pp.791-799
06/01/2023
DOI: 10.3855/jidc.17371
PMID: 37406065
Abstract
Introduction: There have been some reports of the association between SARS-CoV-2 infection and mucormycosis. This study aims to compare the hospitalization rates and clinical characteristics of mucormycosis before and during the COVID-19 pandemic.Methodology: In this retrospective study, we compared the hospitalization rate of mucormycosis patients in Namazi hospital in Southern Iran for two periods of 40 months. We defined July 1st, 2018 to February 17th, 2020, as the pre-COVID-19 period and February 18th, 2020, to September 30th, 2021, as the COVID-19 period. In addition, a quadrupled group of hospitalized patients with age and sex-matched SARS-COV-2 infection without any sign of mucormycosis was selected as the control group for COVID-associated mucormycosis.Result: In the total of 72 mucormycosis patients in the COVID period, 54 patients had a clinical history and a positive RT-PCR, which confirms the diagnosis of SARS-COV2 infection. The hospitalization rate of mucormycosis showed an increase of + 306% (95% CI: + 259%, + 353%) from a monthly average value of 0.26 (95% confidence interval (CI): 0.14, 0.38) in the pre-COVID period to 1.06 in the COVID period. The use of corticosteroids prior to the initiation of hospitalization (p & LE; 0.01), diabetes (DM) (p = 0.04), brain involvement (p = 0.03), orbit involvement (p = 0.04), and sphenoid sinus invasion (p & LE; 0.01) were more common in patients with mucormycosis during the COVID period.Conclusions: In high-risk patients, especially diabetics, special care to avoid the development of mucormycosis must be taken into account in patients with SARS-COV-2 infection considered for treatment with corticosteroids.
Details
- Title: Subtitle
- The hospitalization rate and clinical characteristics of mucormycosis prior and during COVID-19 pandemic: A single-center study
- Creators
- Mehrdad Estakhr - Shiraz University of Medical SciencesZahra Ghotbi - Shiraz University of Medical SciencesMahtab Rostamihosseinkhani - Shiraz University of Medical SciencesEtrat Hooshmandi - Shiraz University of Medical SciencesMasoud Janipour - Shiraz University of Medical SciencesVahid Reza Ostovan - Shiraz University of Medical SciencesNima Fadakar - Shiraz University of Medical SciencesHanieh Bazrafshan - Shiraz University of Medical SciencesZahra Bahrami - Shiraz University of Medical SciencesAbbas Rahimi-Jaberi - Shiraz UniversityMaryam Poursadeghfard - Shiraz University of Medical SciencesMasoumeh Nazeri - Shiraz UniversityPariya Kouhi - Shiraz University of Medical SciencesPeyman Petramfar - Shiraz University of Medical SciencesSadegh Izadi - Shiraz University of Medical SciencesZohreh Barzegar - Shiraz University of Medical SciencesEhsan Nikzadeh - Shiraz University of Medical SciencesSarvin Sasannia - Shiraz University of Medical SciencesShahram Arsang-Jang - Zanjan University of Medical SciencesReza Tabrizi - Fasa University of Medical SciencesBehzad Khademi - Shiraz University of Medical SciencesMahsa Kohandel-Shirazi - Shiraz University of Medical SciencesMohammad Saied Salehi - Shiraz University of Medical SciencesNahid Ashjazadeh - Shiraz University of Medical SciencesBijan Khademi - Shiraz University of Medical SciencesMohammad Javad Ashraf - Shiraz University of Medical SciencesOwrang Eilami - Shiraz University of Medical SciencesAmir Roudgari - Shiraz University of Medical SciencesMohsen Moghaddami - Fasa University of Medical SciencesKamiar Zomorodian - Shiraz University of Medical SciencesHamid Badali - Texas Center for Infectious DiseaseAfshin Borhani-Haghighi - Shiraz University of Medical Sciences
- Resource Type
- Journal article
- Publication Details
- Journal of infection in developing countries, Vol.17(6), pp.791-799
- DOI
- 10.3855/jidc.17371
- PMID
- 37406065
- NLM abbreviation
- J Infect Dev Ctries
- ISSN
- 1972-2680
- eISSN
- 1972-2680
- Publisher
- J Infection Developing Countries
- Number of pages
- 9
- Language
- English
- Date published
- 06/01/2023
- Academic Unit
- Neurology
- Record Identifier
- 9985013726702771
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