Journal article
The human Hsp70B gene at the HSPA7 locus of chromosome 1 is transcribed but non-functional
Biochimica et biophysica acta. Gene structure and expression, Vol.1494(1), pp.201-205
2000
DOI: 10.1016/S0167-4781(00)00203-7
PMID: 11072087
Abstract
The human heat-inducible Hsp70B and Hsp70B′ genes were co-localized to 1q23.1 by in situ hybridization. However, though transcripts from Hsp70B could be detected in heat-shocked cells, DNA sequence analyses of both the gene and cDNA copies of the mRNA indicate the gene is non-functional. Moreover, mouse homologues of Hsp70B/B′ were not detected by Southern blot analysis, suggesting Hsp70B/B′ arose from either Hsp70-1or Hsp70-2 after the divergence of mice and humans.
Details
- Title: Subtitle
- The human Hsp70B gene at the HSPA7 locus of chromosome 1 is transcribed but non-functional
- Creators
- Azemat J Parsian - Department of Radiation Oncology, Division of Medical Genetics, Washington University School of Medicine, St. Louis, MO 63108, USAJamie E Sheren - Department of Radiation Oncology, Division of Medical Genetics, Washington University School of Medicine, St. Louis, MO 63108, USATing Y Tao - Department of Radiation Oncology, Division of Medical Genetics, Washington University School of Medicine, St. Louis, MO 63108, USAPrabhat C Goswami - Department of Radiation Oncology, Division of Medical Genetics, Washington University School of Medicine, St. Louis, MO 63108, USARobert Malyapa - Department of Radiation Oncology, Division of Medical Genetics, Washington University School of Medicine, St. Louis, MO 63108, USARichard Van Rheeden - Department of Pediatrics, Division of Medical Genetics, Washington University School of Medicine, St. Louis, MO 63108, USAMichael S Watson - Department of Pediatrics, Division of Medical Genetics, Washington University School of Medicine, St. Louis, MO 63108, USAClayton R Hunt - Department of Radiation Oncology, Division of Medical Genetics, Washington University School of Medicine, St. Louis, MO 63108, USA
- Resource Type
- Journal article
- Publication Details
- Biochimica et biophysica acta. Gene structure and expression, Vol.1494(1), pp.201-205
- DOI
- 10.1016/S0167-4781(00)00203-7
- PMID
- 11072087
- NLM abbreviation
- Biochim Biophys Acta
- ISSN
- 0167-4781
- eISSN
- 1879-2634
- Publisher
- Elsevier B.V
- Language
- English
- Date published
- 2000
- Academic Unit
- Radiation Oncology
- Record Identifier
- 9984047745702771
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