Journal article
The human immunodeficiency virus-1 genotype diversity and drug resistance mutations profile of volunteer blood donors from Chinese blood centers
Transfusion (Philadelphia, Pa.), Vol.52(5), pp.1041-1049
05/2012
DOI: 10.1111/j.1537-2995.2011.03415.x
PMID: 22044422
Abstract
The global human immunodeficiency virus (HIV)-1 epidemic is becoming increasingly diverse and complex. Molecular epidemiologic characteristics were studied for HIV-1-infected blood donors from five Chinese regions to determine genotype diversity and drug resistance mutations (DRMs) profile.
HIV-1 confirmed-reactive serum samples were collected from 172 blood donors from five blood centers during 2007 to 2010. HIV-1 Pol including whole protease and partial reverse transcriptase genes was amplified, sequenced, and analyzed for the subtype determination and drug resistance profile description.
A total of 113 amplified sequences including 82 from Kunming blood center and 31 from four other blood centers had the following genotype characteristics: G (0.9%), B (2.7%), circulating recombinant form (CRF) 01_AE (32.7%), CRF07_BC (22.1%), and CRF08_BC (41.6%). Female donors represent 45.1% of all cases and 63.9% cases with DRMs. The prevalence of samples with potential low or higher resistance among Chinese blood donors is 4.4%.
HIV-1 infection in Chinese blood donors is genetically diverse and the subtype distribution reflects that from the high-risk populations. Our results support continuous molecular epidemiologic surveillance for HIV-1 in blood donors as a part of a comprehensive HIV control program.
Details
- Title: Subtitle
- The human immunodeficiency virus-1 genotype diversity and drug resistance mutations profile of volunteer blood donors from Chinese blood centers
- Creators
- Peibin Zeng - Institute of Blood Transfusion, Chinese Academy of Medical Sciences, Chengdu, Sichuan, ChinaJingxing WangYi HuangXiaoming GuoJulin LiGuoxin WenTonghan YangZhongqiao YunMiao HeYu LiuYuzhe YuanJane SchulmannSimone GlynnPaul NessJ Brooks JacksonHua Shan
- Resource Type
- Journal article
- Publication Details
- Transfusion (Philadelphia, Pa.), Vol.52(5), pp.1041-1049
- Publisher
- United States
- DOI
- 10.1111/j.1537-2995.2011.03415.x
- PMID
- 22044422
- ISSN
- 0041-1132
- eISSN
- 1537-2995
- Language
- English
- Date published
- 05/2012
- Academic Unit
- Pathology; VPMA - Administration
- Record Identifier
- 9984047897602771
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