Journal article
The hydrazide/hydrazone click reaction as a biomolecule labeling strategy for M(CO)3 (M = Re, 99mTc) radiopharmaceuticals
Chemical communications (Cambridge, England), Vol.47(48), pp.12846-12848
12/28/2011
DOI: 10.1039/c1cc15451f
PMCID: PMC3236597
PMID: 22044929
Abstract
Facile reactivity of hydrazides and aldehydes was explored as potential coupling partners for incorporation into M(CO)
3
(M = Re,
99m
Tc) based radiopharmaceuticals. Both ‘click, then chelate’ and ‘prelabel, then click’ synthetic routes produced identical products in high yields and lacked metal-hydrazide/-hydrazone interactions, highlighting the potential of this click strategy.
Details
- Title: Subtitle
- The hydrazide/hydrazone click reaction as a biomolecule labeling strategy for M(CO)3 (M = Re, 99mTc) radiopharmaceuticals
- Creators
- Tanushree Ganguly - Department of Chemistry, Washington State University, Pullman WA 99164, USA; Fax: 509-335-8867; Tel: 509-335-3858 Department of Chemistry, University of Iowa, Iowa City, IA 52242-1294, USA; Fax: 319-335-1270; Tel: 319-335-3504Benjamin B Kasten - Department of Chemistry, Washington State University, Pullman WA 99164, USA; Fax: 509-335-8867; Tel: 509-335-3858 Department of Chemistry, University of Iowa, Iowa City, IA 52242-1294, USA; Fax: 319-335-1270; Tel: 319-335-3504Dejan-Krešimir Bučar - Department of Chemistry, Washington State University, Pullman WA 99164, USA; Fax: 509-335-8867; Tel: 509-335-3858 Department of Chemistry, University of Iowa, Iowa City, IA 52242-1294, USA; Fax: 319-335-1270; Tel: 319-335-3504Leonard R MacGillivray - Department of Chemistry, Washington State University, Pullman WA 99164, USA; Fax: 509-335-8867; Tel: 509-335-3858 Department of Chemistry, University of Iowa, Iowa City, IA 52242-1294, USA; Fax: 319-335-1270; Tel: 319-335-3504Clifford E Berkman - Department of Chemistry, Washington State University, Pullman WA 99164, USA; Fax: 509-335-8867; Tel: 509-335-3858 Department of Chemistry, University of Iowa, Iowa City, IA 52242-1294, USA; Fax: 319-335-1270; Tel: 319-335-3504Paul D Benny - Department of Chemistry, Washington State University, Pullman WA 99164, USA; Fax: 509-335-8867; Tel: 509-335-3858 Department of Chemistry, University of Iowa, Iowa City, IA 52242-1294, USA; Fax: 319-335-1270; Tel: 319-335-3504
- Resource Type
- Journal article
- Publication Details
- Chemical communications (Cambridge, England), Vol.47(48), pp.12846-12848
- DOI
- 10.1039/c1cc15451f
- PMID
- 22044929
- PMCID
- PMC3236597
- NLM abbreviation
- Chem Commun (Camb)
- ISSN
- 1359-7345
- eISSN
- 1364-548X
- Publisher
- Royal Society of Chemistry
- Grant note
- T32 GM008336-22 || GM / National Institute of General Medical Sciences : NIGMS T32 GM008336-21 || GM / National Institute of General Medical Sciences : NIGMS
- Language
- English
- Date published
- 12/28/2011
- Academic Unit
- Pharmaceutical Sciences and Experimental Therapeutics; Chemistry
- Record Identifier
- 9984216706102771
Metrics
6 Record Views