Journal article
The iPLA(2)gamma is identified as the membrane potential sensitive phospholipase in liver mitochondria
FEBS letters, Vol.589(18), pp.2367-2371
08/19/2015
DOI: 10.1016/j.febslet.2015.07.016
PMID: 26206229
Abstract
Previous reports from our lab identified a mitochondrial calcium-independent phospholipase Ay activity that is activated when the mitochondrial membrane potential is decreased. This activity was demonstrated to influence occurrence of the permeability transition. Originally, this activity was ascribed to the iPLA(2)beta protein. Recently, both iPLA(2)beta and iPLA(2)gamma knock out mice have been generated. It has been shown by others that the iPLA(2)gamma plays a significant role in progression of the permeability transition. In this paper, using the iPLA(2)beta and iPLA(2)gamma knock out mice we show that the membrane potential sensitive activity is the iPLA(2)gamma. (C) 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Details
- Title: Subtitle
- The iPLA(2)gamma is identified as the membrane potential sensitive phospholipase in liver mitochondria
- Creators
- Adam J. Rauckhorst - The Ohio State UniversityDouglas R. Pfeiffer - The Ohio State UniversityKimberly M. Broekemeier - Ohio Northern University
- Resource Type
- Journal article
- Publication Details
- FEBS letters, Vol.589(18), pp.2367-2371
- DOI
- 10.1016/j.febslet.2015.07.016
- PMID
- 26206229
- NLM abbreviation
- FEBS Lett
- ISSN
- 0014-5793
- eISSN
- 1873-3468
- Publisher
- Wiley
- Number of pages
- 5
- Grant note
- Department of Chemistry and Biochemistry at Ohio Northern University Ellie Kovalcik Research Foundation
- Language
- English
- Date published
- 08/19/2015
- Academic Unit
- Molecular Physiology and Biophysics
- Record Identifier
- 9984446514502771
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