Journal article
The idiopathic intracranial hypertension treatment trial: clinical profile at baseline
JAMA neurology, Vol.71(6), pp.693-701
06/2014
DOI: 10.1001/jamaneurol.2014.133
PMCID: PMC4351808
PMID: 24756302
Abstract
To our knowledge, there are no large prospective cohorts of untreated patients with idiopathic intracranial hypertension (IIH) to characterize the disease. To report the baseline clinical and laboratory features of patients enrolled in the Idiopathic Intracranial Hypertension Treatment Trial. We collected data at baseline from questionnaires, examinations, automated perimetry, and fundus photography grading. Patients (n = 165) were enrolled from March 17, 2010, to November 27, 2012, at 38 academic and private practice sites in North America. All participants met the modified Dandy criteria for IIH and had a perimetric mean deviation between -2 dB and -7 dB. All but 4 participants were women. Baseline and laboratory characteristics. The mean (SD) age of our patients was 29.0 (7.4) years and 4 (2.4%) were men. The average (SD) body mass index (calculated as weight in kilograms divided by height in meters squared) was 39.9 (8.3). Headache was the most common symptom (84%). Transient visual obscurations occurred in 68% of patients, back pain in 53%, and pulse synchronous tinnitus in 52%. Only 32% reported visual loss. The average (SD) perimetric mean deviation in the worst eye was -3.5 (1.1) dB, (range, -2.0 to -6.4 dB) and in the best eye was -2.3 (1.1) dB (range, -5.2 to 0.8 dB). A partial arcuate visual field defect with an enlarged blind spot was the most common perimetric finding. Visual acuity was 85 letters or better (20/20) in 71% of the worst eyes and 77% of the best eyes. Quality of life measures, including the National Eye Institute Visual Function Questionnaire-25 and the Short Form-36 physical and mental health summary scales, were lower compared with population norms. The Idiopathic Intracranial Hypertension Treatment Trial represents the largest prospectively analyzed cohort of untreated patients with IIH. Our data show that IIH is almost exclusively a disease of obese young women. Patients with IIH with mild visual loss have typical symptoms, may have mild acuity loss, and have visual field defects, with predominantly arcuate loss and enlarged blind spots that require formal perimetry for detection. clinicaltrials.gov Identifier: NCT01003639.
Details
- Title: Subtitle
- The idiopathic intracranial hypertension treatment trial: clinical profile at baseline
- Creators
- Michael Wall - University of Iowa, NeurologyMark J Kupersmith - St. Luke's-Roosevelt Hospital CenterKarl D Kieburtz - University of RochesterJames J Corbett - University of Mississippi Medical CenterSteven E Feldon - University of RochesterDeborah I Friedman - The University of Texas Southwestern Medical CenterDavid M KatzJohn L Keltner - Department of Ophthalmology, University of California-DavisEleanor B Schron - Division of Extramural Research, National Eye Institute, Bethesda, MarylandMichael P McDermott - University of RochesterNORDIC Idiopathic Intracranial Hypertension Study Group
- Resource Type
- Journal article
- Publication Details
- JAMA neurology, Vol.71(6), pp.693-701
- DOI
- 10.1001/jamaneurol.2014.133
- PMID
- 24756302
- PMCID
- PMC4351808
- NLM abbreviation
- JAMA Neurol
- ISSN
- 2168-6149
- eISSN
- 2168-6157
- Publisher
- United States
- Grant note
- 3U10EY017281-01A1S2 / NEI NIH HHS 1U10EY017281-01A1 / NEI NIH HHS 3U10EY017281-01A1S1 / NEI NIH HHS 1U10EY017387-01A1S1 / NEI NIH HHS U10 EY017387 / NEI NIH HHS U10 EY017281 / NEI NIH HHS 1U10EY017387-01A1 / NEI NIH HHS
- Language
- English
- Date published
- 06/2014
- Academic Unit
- Neurology; Ophthalmology and Visual Sciences
- Record Identifier
- 9983980062702771
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