Journal article
The immunobiology and clinical potential of immunostimulatory CpG oligodeoxynucleotides
Journal of leukocyte biology, Vol.68(4), pp.455-463
10/2000
DOI: 10.1189/jlb.68.4.455
PMID: 11037965
Abstract
Over 100 years ago, Coley first explored the use of bacterial products as immunostimulatory therapy for nonbacterial disease. It is now clear that bacterial DNA, and synthetic oligodeoxynucleotides containing specific motifs centered on a CpG dinucleotide (CpG ODN), are potent immunostimulatory agents. The molecular mechanisms responsible for the immunostimulatory effects of CpG ODN have yet to be elucidated fully, although it is clear that CpG ODN act rapidly on a variety of cell types. This includes activation of B cells, natural killer cells, and antigen-presenting cells including monocytes, macrophages, and dendritic cells. These effects have led to evaluation of CpG ODN as immune adjuvants in immunization where they have been shown in animal models to enhance the development of a TH1-type immune response. Preliminary results from clinical trials using CpG ODN as an immune adjuvant are promising. Preclinical studies suggest CpG ODN can also enhance innate immunity against a variety of infections, synergize with monoclonal antibody to enhance antibody-dependent cellular cytotoxicity, and alter the Th1/Th2 balance as a possible treatment for allergic diseases and asthma. Clinical evaluation has recently begun to determine whether promising preclinical results with CpG ODN can be translated into effective and tolerable clinical treatment approaches.
Details
- Title: Subtitle
- The immunobiology and clinical potential of immunostimulatory CpG oligodeoxynucleotides
- Creators
- George J. Weiner - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Journal of leukocyte biology, Vol.68(4), pp.455-463
- DOI
- 10.1189/jlb.68.4.455
- PMID
- 11037965
- ISSN
- 0741-5400
- eISSN
- 1938-3673
- Grant note
- DOI: 10.13039/100000002, name: National Institutes of Health, award: R01 CA77764
- Language
- English
- Date published
- 10/2000
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Pharmaceutical Sciences and Experimental Therapeutics; Internal Medicine
- Record Identifier
- 9984359925402771
Metrics
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