Journal article
The immunology of sarcoidosis
Clinics in chest medicine, Vol.29(3), pp.379-390
09/2008
DOI: 10.1016/j.ccm.2008.03.014
PMID: 18539233
Abstract
Sarcoidosis continues to be a disease of research interest because of its complicated immune mechanisms and elusive etiology. So far, it has been established that granulomatous inflammation in sarcoidosis is predominantly a T-helper 1 immune response mediated by a complex network of lymphocytes, macrophages, and cytokines. The cause of progression to a chronic and potentially fibrotic form is unclear but may involve loss of apoptotic mechanisms, loss of regulatory response, or a persistent antigen that cannot be cleared. Recent genomic and proteomic technology has emphasized the importance of host susceptibility and gene-environment interaction in the expression of the disease.
Details
- Title: Subtitle
- The immunology of sarcoidosis
- Creators
- Alicia K Gerke - Division of Pulmonary, Critical Care, and Occupational Medicine, University of Iowa College of Medicine, 200 Hawkins Drive, Iowa City, IA 52242, USA. alicia-gerke@uiowa.eduGary Hunninghake
- Resource Type
- Journal article
- Publication Details
- Clinics in chest medicine, Vol.29(3), pp.379-390
- DOI
- 10.1016/j.ccm.2008.03.014
- PMID
- 18539233
- ISSN
- 0272-5231
- eISSN
- 1557-8216
- Language
- English
- Date published
- 09/2008
- Academic Unit
- Pulmonary, Critical Care, and Occupational Medicine; Internal Medicine
- Record Identifier
- 9984094756202771
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