Journal article
The impact of DNA testing on management of patients with colorectal cancer
Annals of gastroenterological surgery, Vol.6(1), pp.17-28
01/01/2022
DOI: 10.1002/ags3.12526
PMCID: PMC8786701
PMID: 35106411
Abstract
Knowledge of the genetic basis of colorectal cancer has evolved over the past decades, allowing for the pre-symptomatic identification of affected patients in those with familial syndromes and to the understanding of the multi-step progression to carcinogenesis in tumors. Knowledge of the genes and pathways involved in colorectal cancer has allowed for targeted therapies in patients in addition to standard chemotherapy for those with metastases. Next-generation sequencing technologies have now also allowed for the sensitive detection of circulating mutations derived from tumors, which can give insight into the presence of residual disease and has implications for changing the standard paradigms for treatment. This article will specifically review advances in targeted therapy in metastatic colon cancer and the progress being made in using circulating tumor DNA in patient management.
Details
- Title: Subtitle
- The impact of DNA testing on management of patients with colorectal cancer
- Creators
- James R. Howe - Roy J. and Lucille A. Carver College of Medicine
- Resource Type
- Journal article
- Publication Details
- Annals of gastroenterological surgery, Vol.6(1), pp.17-28
- DOI
- 10.1002/ags3.12526
- PMID
- 35106411
- PMCID
- PMC8786701
- NLM abbreviation
- Ann Gastroenterol Surg
- ISSN
- 2475-0328
- eISSN
- 2475-0328
- Publisher
- Wiley
- Number of pages
- 12
- Grant note
- P50 CA174521-01 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Language
- English
- Date published
- 01/01/2022
- Academic Unit
- Surgery
- Record Identifier
- 9984322956502771
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