Journal article
The impact of a Dysbindin schizophrenia susceptibility variant on fiber tract integrity in healthy individuals: A TBSS-based diffusion tensor imaging study
NeuroImage (Orlando, Fla.), Vol.60(2), pp.847-853
04/02/2012
DOI: 10.1016/j.neuroimage.2011.10.012
PMID: 22019876
Abstract
Schizophrenia is a severe neuropsychiatric disorder with high heritability, though its exact etiopathogenesis is yet unknown. An increasing number of studies point to the importance of white matter anomalies in the pathophysiology of schizophrenia. While several studies have identified the impact of schizophrenia susceptibility gene variants on gray matter anatomy in both schizophrenia patients and healthy risk variant carriers, studies dealing with the impact of these gene variants on white matter integrity are still scarce. We here present a study on the effects of a Dysbindin schizophrenia susceptibility gene variant on fiber tract integrity in healthy young subjects.
Details
- Title: Subtitle
- The impact of a Dysbindin schizophrenia susceptibility variant on fiber tract integrity in healthy individuals: A TBSS-based diffusion tensor imaging study
- Creators
- Thomas Nickl-Jockschat - Department of Psychiatry and Psychotherapy, RWTH Aachen University, Aachen, GermanyTony Stöcker - Juelich Aachen Research Alliance - Translational Brain Medicine, GermanyValentin Markov - Department of Psychiatry and Psychotherapy, RWTH Aachen University, Aachen, GermanyAxel Krug - Department of Psychiatry and Psychotherapy, University of Marburg, Marburg, GermanyRuihuang Huang - Juelich Aachen Research Alliance - Translational Brain Medicine, GermanyFrank Schneider - Department of Psychiatry and Psychotherapy, RWTH Aachen University, Aachen, GermanyUte Habel - Department of Psychiatry and Psychotherapy, RWTH Aachen University, Aachen, GermanyKlaus Zerres - Institute of Human Genetics, RWTH Aachen University, Aachen, GermanyMarkus M Nöthen - Department of Genomics, Life & Brain Center, University of Bonn, Bonn, GermanyJens Treutlein - Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, GermanyMarcella Rietschel - Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, GermanyN Jon Shah - Juelich Aachen Research Alliance - Translational Brain Medicine, GermanyTilo Kircher - Department of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany
- Resource Type
- Journal article
- Publication Details
- NeuroImage (Orlando, Fla.), Vol.60(2), pp.847-853
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.neuroimage.2011.10.012
- PMID
- 22019876
- ISSN
- 1053-8119
- eISSN
- 1095-9572
- Language
- English
- Date published
- 04/02/2012
- Academic Unit
- Psychiatry; Neuroscience and Pharmacology
- Record Identifier
- 9984003947802771
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