Journal article
The impact of a gonadotropin-releasing hormone antagonist on gonadotropin ovulation induction cycles in women with polycystic ovary syndrome: a prospective randomized study
Fertility and Sterility, Vol.95(1), pp.216-220
0
2011
DOI: 10.1016/j.fertnstert.2010.05.023
Abstract
To evaluate the effect of the gonadotropin-releasing hormone antagonist Ganirelix on gonadotropin ovulation induction (OI) in patients with polycystic ovary syndrome (PCOS). Prospective, randomized, controlled study. Academic infertility center. Ninety-eight anovulatory women with PCOS undergoing 154 gonadotropin OI cycles. Patients were treated with recombinant FSH alone (group 1) or in conjunction with Ganirelix when the leading follicle was ≥13 mm (group 2) versus from the beginning of stimulation (group 3), followed by IUI. Per cycle clinical pregnancy rate (CPR), live-birth rate (LBR), total gonadotropin dose, days of stimulation, serum LH and peak E , and premature luteinization rate. Data are suggestive of improved CPR in group 2 versus group 1 (33% vs. 19%) and LBR (35% vs. 20%) but not significantly different. Premature luteinization was highest in group 1 (21% vs. 1.8% in group 2 and 2.1% in group 3). Group 3 had the highest cancellation rate and cost without improving CPR and LBR. No differences were noted in peak serum E , total gonadotropin dose, or days of stimulation. Adding Ganirelix in a flexible protocol to gonadotropin OI cycles in women with PCOS may be beneficial by decreasing premature luteinization.
Details
- Title: Subtitle
- The impact of a gonadotropin-releasing hormone antagonist on gonadotropin ovulation induction cycles in women with polycystic ovary syndrome: a prospective randomized study
- Creators
- Laurel A StadtmauerAbbaa SarhanE. Hakan Duran - University of Iowa, Obstetrics and GynecologyHind BeydounSilvina BoccaBeth PultzSergio Oehninger
- Resource Type
- Journal article
- Publication Details
- Fertility and Sterility, Vol.95(1), pp.216-220
- Event
- 0
- DOI
- 10.1016/j.fertnstert.2010.05.023
- ISSN
- 0015-0282
- eISSN
- 1556-5653
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 2011
- Academic Unit
- Obstetrics and Gynecology
- Record Identifier
- 9983557123502771
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