The impact of antioxidant and splanchnic-directed therapy on persistent uncorrected gastric mucosal pH in the critically injured trauma patient

Erik Barquist; Orlando Kirton; Jimmy Windsor; Judith Hudson-Civetta; Mauricio Lynn; Michael Herman; Joseph Civetta

doi:10.1097/00005373-199802000-00022

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Journal article

The impact of antioxidant and splanchnic-directed therapy on persistent uncorrected gastric mucosal pH in the critically injured trauma patient

Erik Barquist, Orlando Kirton, Jimmy Windsor, Judith Hudson-Civetta, Mauricio Lynn, Michael Herman and Joseph Civetta

The journal of trauma, Vol.44(2), pp.355-360

02/1998

DOI: 10.1097/00005373-199802000-00022

PMID: 9498511

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Abstract

Critically ill trauma patients with gastric intramucosal acidosis, as measured by gastric tonometry, have an increased incidence of multiple organ dysfunction syndrome despite supranormal O2 delivery. We altered our resuscitation protocol to maximize splanchnic blood flow and decrease oxygen-derived free radical damage.

Folic Acid - therapeutic use

Prospective Studies

Acidosis - etiology

Vasodilator Agents - therapeutic use

Acidosis - drug therapy

Humans

Cardiac Output

Diuretics, Osmotic - therapeutic use

Mannitol - therapeutic use

Wounds and Injuries - complications

Critical Illness

Wounds and Injuries - physiopathology

Cardiotonic Agents - therapeutic use

Wounds and Injuries - mortality

Wounds and Injuries - classification

Antioxidants - therapeutic use

Multiple Organ Failure - prevention & control

Acidosis - diagnosis

Gastric Acidity Determination

Gastric Mucosa - physiopathology

Isoproterenol - therapeutic use

Dobutamine - therapeutic use

APACHE

Hydrogen-Ion Concentration

Details

Title: Subtitle: The impact of antioxidant and splanchnic-directed therapy on persistent uncorrected gastric mucosal pH in the critically injured trauma patient
Creators: Erik Barquist - Department of Surgery, University of Rochester School of Medicine, New York 14642, USA
Orlando Kirton
Jimmy Windsor
Judith Hudson-Civetta
Mauricio Lynn
Michael Herman
Joseph Civetta
Resource Type: Journal article
Publication Details: The journal of trauma, Vol.44(2), pp.355-360
Publisher: United States
DOI: 10.1097/00005373-199802000-00022
PMID: 9498511
ISSN: 0022-5282
eISSN: 1529-8809
Language: English
Date published: 02/1998
Academic Unit: Anesthesia
Record Identifier: 9984007176902771

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