Journal article
The impact of elexacaftor/tezacaftor/ivacaftor on body composition in a small cohort of youth with cystic fibrosis
Pediatric pulmonology, Vol.58(6), pp.1805-1811
06/2023
DOI: 10.1002/ppul.26388
PMID: 36929859
Abstract
The effects of elexacaftor-tezacaftor-ivacaftor (ETI) on body composition in people with CF (pwCF) are unknown.
Dual-energy X-ray absorptiometry fat-free mass and fat mass adjusted for height (FMI) as well as oral glucose tolerance test derived measures of insulin secretion and sensitivity were compared before and after ETI initiation in eight pwCF.
Patients median age: 22 years interquartile range (IQR: 16-28), 87.5% male, median time on ETI:11 months. Weight z-score increased from -0.52 to 0.18 (p = 0.014); FMI increased from 4.12 to 6.29 (p = 0.014). Insulin secretion (C pep iAUC/Gluc iAUC) increased from 8.71 to 14.21 (p = 0.021), insulin resistance (HOMA2 IR) increased from 0.73 to 1.25 (p = 0.014) and insulin sensitivity decreased (Matsuda) 8.88 to 5.58 (p = 0.036).
ETI resulted in increased weight and fat mass. BMI and muscle mass did not change. Both insulin secretion and insulin resistance increased. Longer-term metabolic consequences of ETI need further investigation.
Details
- Title: Subtitle
- The impact of elexacaftor/tezacaftor/ivacaftor on body composition in a small cohort of youth with cystic fibrosis
- Creators
- Andrea Granados - Miami Children's HospitalChristine L Chan - University of Colorado Anschutz Medical CampusAmir Moheet - University of MinnesotaTimothy Vigers - University of Colorado Anschutz Medical CampusAna María Arbeláez - Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri, USAKatie Larson Ode - Fraternal Order of Eagles Diabetes Research Center, University of Iowa, Iowa City, Iowa, USA
- Resource Type
- Journal article
- Publication Details
- Pediatric pulmonology, Vol.58(6), pp.1805-1811
- DOI
- 10.1002/ppul.26388
- PMID
- 36929859
- NLM abbreviation
- Pediatr Pulmonol
- ISSN
- 8755-6863
- eISSN
- 1099-0496
- Grant note
- Cystic Fibrosis Foundation
- Language
- English
- Electronic publication date
- 03/17/2023
- Date published
- 06/2023
- Academic Unit
- Endocrinology and Diabetes; Stead Family Department of Pediatrics
- Record Identifier
- 9984378113802771
Metrics
17 Record Views