Journal article
The impact of fluid balance on outcomes in premature neonates: a report from the AWAKEN study group
Pediatric research, Vol.87(3), pp.550-557
02/2020
DOI: 10.1038/s41390-019-0579-1
PMCID: PMC7036003
PMID: 31537009
Abstract
We evaluated the epidemiology of fluid balance (FB) over the first postnatal week and its impact on outcomes in a multi-center cohort of premature neonates from the AWAKEN study.
Retrospective analysis of infants <36 weeks' gestational age from the AWAKEN study (N = 1007). FB was defined by percentage of change from birth weight.
Mechanical ventilation (MV) at postnatal day 7.
One hundred and forty-nine (14.8%) were on MV at postnatal day 7. The median peak FB was 0% (IQR: -2.9, 2) and occurred on postnatal day 2 (IQR: 1,5). Multivariable models showed that the peak FB (aOR 1.14, 95% CI 1.10-1.19), lowest FB in first postnatal week (aOR 1.12, 95% CI 1.07-1.16), and FB on postnatal day 7 (aOR 1.10, 95% CI 1.06-1.13) were independently associated with MV on postnatal day 7. In a similar analysis, a negative FB at postnatal day 7 protected against the need for MV at postnatal day 7 (aOR 0.21, 95% CI 0.12-0.35).
Positive peak FB during the first postnatal week and more positive FB on postnatal day 7 were independently associated with MV at postnatal day 7. Those with a negative FB at postnatal day 7 were less likely to require MV.
Details
- Title: Subtitle
- The impact of fluid balance on outcomes in premature neonates: a report from the AWAKEN study group
- Creators
- David T Selewski - Medical University of South CarolinaKatja M Gist - Children's Hospital ColoradoAmy T Nathan - Cincinnati Children's Hospital Medical CenterStuart L Goldstein - Cincinnati Children's Hospital Medical CenterLouis J Boohaker - University of Alabama at BirminghamAyse Akcan-Arikan - Baylor College of MedicineElizabeth M Bonachea - Nationwide Children's HospitalMina Hanna - University of KentuckyCatherine Joseph - Baylor College of MedicineJohn D Mahan - The Ohio State UniversityCherry Mammen - British Columbia Children's HospitalArwa Nada - University of Tennessee Health Science CenterKimberly Reidy - The Bronx DefendersAmy Staples - University of New MexicoPia Wintermark - McGill UniversityRussell Griffin - University of Alabama at BirminghamDavid J Askenazi - University of Alabama at BirminghamRonnie Guillet - Golisano Children's HospitalNeonatal Kidney Collaborative
- Contributors
- Tarah T Colaizy (Contributor) - University of Iowa, NeonatologyJonathan M Klein (Contributor) - University of Iowa, Neonatology
- Resource Type
- Journal article
- Publication Details
- Pediatric research, Vol.87(3), pp.550-557
- DOI
- 10.1038/s41390-019-0579-1
- PMID
- 31537009
- PMCID
- PMC7036003
- ISSN
- 0031-3998
- eISSN
- 1530-0447
- Grant note
- K08 DK109226 / NIDDK NIH HHS UL1 TR001417 / NCATS NIH HHS UL1 TR003096 / NCATS NIH HHS
- Language
- English
- Date published
- 02/2020
- Academic Unit
- Stead Family Department of Pediatrics; Neonatology
- Record Identifier
- 9984353888802771
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