Journal article
The impact of incidental gastrointestinal stromal tumours on patients undergoing resection of upper gastrointestinal neoplasms
Canadian journal of surgery, Vol.55(6), pp.366-370
12/2012
DOI: 10.1503/cjs.009111
PMCID: PMC3506684
PMID: 22992402
Abstract
Background: Emerging data suggest asymptomatic gastrointestinal stromal tumours (GISTs) of the upper gastrointestinal (UGI) tract are not uncommon. We sought to determine their incidence in patients undergoing resection for UGI neoplasms and their impact on surgical and adjuvant treatment.
Methods: We accessed a database prospectively listing all patients undergoing resection of non-GIST neoplasms of the stomach and esophagus at a single university centre over a 4.5-year period and reviewed pathology reports for the presence of synchronous GISTs in the UGI tract. We compared patient demographic and tumour characteristics, operative procedures and postoperative outcomes.
Results: In all, 207 patients undergoing gastrectomy or esophagectomy for non- GIST neoplasms were included. We identified 15 synchronous GISTs in the UGI tract of 11 (5.3%) patients (1 preoperatively, 4 intraoperatively and 10 on final pathology), with an average age of 67 years. Most patients were men. Additional resections were required for GISTs identified pre- or intraoperatively. Final pathology revealed completely resected c-kit positive tumours of an average size of 0.5 (range 0.1-4.0) cm with low or very low risk of malignant potential. No patients received adjuvant therapy for the GISTs. After a median follow-up of 11 (range 2-36) months, 5 patients died from their primary cancer, 3 were alive with primary cancer recurrence, and 3 were alive without disease. No patients experienced GIST recurrence.
Conclusion: Incidentally finding a synchronous GIST during resection of UGI neoplasms is not uncommon; it may alter surgical treatment but is unlikely to impact longterm survival.
Details
- Title: Subtitle
- The impact of incidental gastrointestinal stromal tumours on patients undergoing resection of upper gastrointestinal neoplasms
- Creators
- Carlos H.F Chan - Department of Surgery, McGill University Health Centre, Montréal, QueJonathan Cools-Lartigue - Department of Surgery, McGill University Health Centre, Montréal, QueVictoria A Marcus - Department of Pathology, McGill University Health Centre, Montréal, QueLiane S Feldman - Department of Surgery, McGill University Health Centre, Montréal, QueLorenzo E Ferri - Department of Surgery, McGill University Health Centre, Montréal, Que
- Resource Type
- Journal article
- Publication Details
- Canadian journal of surgery, Vol.55(6), pp.366-370
- Publisher
- Canadian Medical Association
- DOI
- 10.1503/cjs.009111
- PMID
- 22992402
- PMCID
- PMC3506684
- ISSN
- 0008-428X
- eISSN
- 1488-2310
- Language
- English
- Date published
- 12/2012
- Academic Unit
- Surgery; Radiation Oncology
- Record Identifier
- 9984047988302771
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