Journal article
The impact of prior risk experiences on subsequent risky decision-making: The role of the insula
NeuroImage (Orlando, Fla.), Vol.50(2), pp.709-716
04/01/2010
DOI: 10.1016/j.neuroimage.2009.12.097
PMCID: PMC2828040
PMID: 20045470
Abstract
Risky decision-making is significantly affected by homeostatic states associated with different prior risk experiences, yet the neural mechanisms have not been well understood. Using functional MRI, we examined how gambling decisions and their underlying neural responses were modulated by prior risk experiences, with a focus on the insular cortex since it has been implicated in interoception, emotion and risky decision-making. Fourteen healthy young participants were scanned while performing a gambling task that was designed to simulate daily-life risk taking. Prior risk experience was manipulated by presenting participants with gambles that they were very likely to accept or gambles that they were unlikely to accept. A probe gamble, which was sensitive to individual's risk preference, was presented to examine the effect of prior risk experiences (Risk vs. Norisk) on subsequent risky decisions. Compared to passing on a gamble (Norisk), taking a gamble, especially winning a gamble (Riskwin), was associated with significantly stronger activation in the insular and dorsal medial prefrontal cortices. Decision making after Norisk was more risky and more likely to recruit activation of the insular and anterior cingulate cortices. This insular activity during decision making predicted the extent of risky decisions both within- and across-subjects, and was also correlated with an individual's personality trait of urgency. These findings suggest that the insula plays an important role in activating representations of homeostatic states associated with the experience of risk, which in turn exerts an influence on subsequent decisions. (C) 2010 Elsevier Inc. All rights reserved.
Details
- Title: Subtitle
- The impact of prior risk experiences on subsequent risky decision-making: The role of the insula
- Creators
- Gui Xue - University of Southern CaliforniaZhonglin Lu - Univ So Calif, Dept Psychol, Los Angeles, CA 90089 USAIrwin P. Levin - University of IowaAntoine Bechara - University of Southern California
- Resource Type
- Journal article
- Publication Details
- NeuroImage (Orlando, Fla.), Vol.50(2), pp.709-716
- DOI
- 10.1016/j.neuroimage.2009.12.097
- PMID
- 20045470
- PMCID
- PMC2828040
- NLM abbreviation
- Neuroimage
- ISSN
- 1053-8119
- eISSN
- 1095-9572
- Publisher
- Elsevier
- Number of pages
- 8
- Grant note
- P50NS019632 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) R01DA023051 / NATIONAL INSTITUTE ON DRUG ABUSE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Drug Abuse (NIDA); European Commission DA11779; DA12487; DA16708 / National Institute on Drug Abuse (NIDA); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Drug Abuse (NIDA) IIS 04-42586; SES 03-50984 / National Science Foundation (NSF)
- Language
- English
- Date published
- 04/01/2010
- Academic Unit
- Marketing; Psychological and Brain Sciences
- Record Identifier
- 9984963222502771
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