Journal article
The impact of repeated organophosphorus pesticide exposure on biomarkers and neurobehavioral outcomes among adolescent pesticide applicators
Journal of Toxicology and Environmental Health, Part A, Vol.80(10-12), pp.542-555
06/18/2017
DOI: 10.1080/15287394.2017.1362612
PMID: 28880741
Abstract
Egyptian adolescents are hired as seasonal workers to apply pesticides to the cotton crop and may perform this occupation for several years. However, few studies examined the effects of repeated pesticide exposure on health outcomes The goal of this study was to determine the impact of repeated pesticide exposure on neurobehavioral (NB) performance and biomarkers of exposure (urinary metabolite) and effect (cholinesterase activity). Eighty-four adolescents from two field stations in Menoufia, Egypt, were examined four times: before and during pesticide application season in 2010 and again before and during application season in 2011. At each of the four time points, participants completed a questionnaire, performed an NB test battery, and were assessed for urinary levels of the chlorpyrifos metabolite TCPy (3,5,6-trichloro-2-pyridinol) and blood cholinesterase activity. Following the study cohort over two consecutive pesticide application seasons revealed that TCPy levels significantly increased following exposure, and returned to baseline levels following the end of the application season. Blood butyryl cholinesterase activity exhibited a similar pattern. Although NB outcomes displayed learning and practice effects over time, deficits in performance were significantly associated with increased TCPy levels with reduction in the number of NB measures showing improvement over time. Biomarkers of exposure and effect demonstrated changes associated with pesticide application and recovery after application ended. Deficits in NB performance were correlated with elevated pesticide exposure. Data demonstrated that repeated pesticide exposure may exert a long-term adverse impact on human health.
Details
- Title: Subtitle
- The impact of repeated organophosphorus pesticide exposure on biomarkers and neurobehavioral outcomes among adolescent pesticide applicators
- Creators
- Ahmed A Ismail - Department of Occupational and Environmental Health, College of Public Health, University of Iowa, Iowa City, IA, USA, Community Medicine and Public Health Department, Faculty of Medicine, Menoufia University, Shebin El-Kom, EgyptKai Wang - Department of Biostatistics, College of Public Health, University of Iowa, Iowa City, IA, USAJames R Olson - Department of Epidemiology and Environmental Health, State University of New York, Buffalo, NY, USA, Department of Pharmacology and Toxicology, State University of New York, Buffalo, NY, USAMatthew R Bonner - Department of Epidemiology and Environmental Health, State University of New York, Buffalo, NY, USAOlfat Hendy - Department of Clinical Pathology, National Liver Institute, Menoufia University, Shebin El-Kom, EgyptGaafar Abdel Rasoul - Community Medicine and Public Health Department, Faculty of Medicine, Menoufia University, Shebin El-Kom, EgyptDiane S Rohlman - Department of Occupational and Environmental Health, College of Public Health, University of Iowa, Iowa City, IA, USA
- Resource Type
- Journal article
- Publication Details
- Journal of Toxicology and Environmental Health, Part A, Vol.80(10-12), pp.542-555
- DOI
- 10.1080/15287394.2017.1362612
- PMID
- 28880741
- NLM abbreviation
- J Toxicol Environ Health A
- ISSN
- 1528-7394
- eISSN
- 1087-2620
- Publisher
- Informa UK Limited
- Grant note
- DOI: 10.13039/100000066, name: National Institute of Environmental Health Sciences, award: R01 ES022163, R21 ES017223
- Language
- English
- Date published
- 06/18/2017
- Academic Unit
- Occupational and Environmental Health; International Programs; Biostatistics; Injury Prevention Research Center
- Record Identifier
- 9983997486702771
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