Journal article
The impact of zoledronic acid on regenerate and native bone after consolidation and removal of the external fixator: An animal model study
Bone (New York, N.Y.), Vol.46(2), pp.363-368
02/01/2010
DOI: 10.1016/j.bone.2009.10.010
PMID: 19837196
Abstract
We investigated the role of zoledronic acid on the regenerate and native bone after consolidation and removal of the external fixator in a rabbit model of distraction osteogenesis using 28 New Zealand white rabbits.
The rabbits were randomly distributed into two groups. The first group received three doses of zoledronic acid (ZA) 0.1 mg/kg subcutaneously at weekly intervals while the second group received injections of sterile saline. Distraction started on day 7 at a rate of 0.8 mm/day for 12 days. At week 3 the average lengthening, regenerate density, and regenerate continuity were comparable between the two groups.
At week 11 the regenerate in the treated group had a significant increase in Bone Mineral Density (BMD) and Bone Mineral Content (BMC) compared to the placebo group. On axial compression, the regenerate showed an increase in the peak load and a higher modulus of elasticity in the treated group. At 6 months, radiographs demonstrated signs of osteopenia of the proximal metaphysis in the control group, and failure of new bone formation around the pin sites in the treated group. BMC and BMD value differences between the two groups were not statistically significant. Histologically, there was persistence of more bone trabeculae in the medullary canal of the regenerate with the persistence of the pin-holes in the treated group. Mechanically, the regenerates in the treated group remain stronger in resisting the axial compression. The proximal fragment in the treated group exhibited a statistically significant decrease in the peak load, toughness and efail %. In conclusion, bisphosphonate-treated rabbits have a stronger regenerate during distraction, and directly after removal of the fixator. They do not develop disuse osteopenia in their lengthened tibia. This treatment may shorten the time in the external fixator and prevent fragility fractures in the treated extremity. However, its long-term safety has not yet been established. (C) 2009 Elsevier Inc. All rights reserved.
Details
- Title: Subtitle
- The impact of zoledronic acid on regenerate and native bone after consolidation and removal of the external fixator: An animal model study
- Creators
- Said Saghieh - American University of Beirut Medical CenterNabil J. Khoury - Amer Univ Beirut, Med Ctr, Dept Diagnost Radiol, Beirut 11072020, LebanonAyman Tawil - Amer Univ Beirut, Med Ctr, Dept Pathol & Lab Med, Beirut 11072020, LebanonKarim Z. Masrouha - Amer Univ Beirut, Div Orthoped Surg, Dept Surg, Med Ctr, Beirut 11072020, LebanonKhaled M. Musallam - Amer Univ Beirut, Med Ctr, Div Hematol & Oncol, Dept Internal Med, Beirut 11072020, LebanonKinda Khalaf - Amer Univ Beirut, Fac Engn, Dept Mech Engn, Beirut 11072020, LebanonLaura Dosh - Amer Univ Beirut, Anim Care Facil, Beirut 11072020, LebanonRosemarie Reich Jaouhari - Amer Univ Beirut, Anim Care Facil, Beirut 11072020, LebanonGhina Birjawi - Amer Univ Beirut, Med Ctr, Dept Diagnost Radiol, Beirut 11072020, LebanonGhada El-Hajj Fuleihan - Amer Univ Beirut, Med Ctr, Dept Internal Med, Div Endocrinol, Beirut 11072020, Lebanon
- Resource Type
- Journal article
- Publication Details
- Bone (New York, N.Y.), Vol.46(2), pp.363-368
- Publisher
- Elsevier
- DOI
- 10.1016/j.bone.2009.10.010
- PMID
- 19837196
- ISSN
- 8756-3282
- eISSN
- 1873-2763
- Number of pages
- 6
- Language
- English
- Date published
- 02/01/2010
- Academic Unit
- Radiology
- Record Identifier
- 9984697720602771
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