Journal article
The impact preload on left ventricular three-plane deformation measurements in extremely premature infants
Early human development, Vol.153, pp.105291-105291
02/01/2021
DOI: 10.1016/j.earlhumdev.2020.105291
PMID: 33310351
Abstract
Background: Left Ventricular (LV) deformation analysis using two-dimensional speckle tracking echocardiography (STE) is an emerging modality in premature infants.
Aims: To assess the impact of increased preload on LV deformation in three planes: longitudinal, circumferential and radial in premature infants.
Study design and subjects: Infants recruited to the PDA RCT (ISRCTN 13281214) and survived to discharge were included with the cohort divided into infants who closed their patent ductus arteriosus (PDA) by Day 8 (Low preload, PDA Closed) and those who maintained ductal patency (high preload, PDA Open). Outcome measures: Longitudinal, circumferential and radial strain and systolic strain rate (SRs) were measured at 36 h, Days 4 & 8 and 36 weeks.
Results: 61 infants were included. The PDA open Group had a lower gestation (26.4 vs. 27.4 weeks,p < 0.01) with a median PDA exposure of 30 days (vs. 2 days, p < 0.01), and demonstrated echocardiography evidence of pulmonary overcirculation. There was higher LV longitudinal strain and SRs over the first 3 scans in the PDA Open Group. Circumferential strain was higher over the first 2 scans while circumferential SRs was higher at 36 h. Radial Strain and SRs were only higher on Day 4.
Conclusion: Increased preload is associated with higher strain and systolic strain rate values in the premature population indicating that preload has a significant effect on deformation measurements in this population across all three planes.
Details
- Title: Subtitle
- The impact preload on left ventricular three-plane deformation measurements in extremely premature infants
- Creators
- Neidin Bussmann - Rotunda HospitalOrla Franklin - Our Lady's HospitalNaomi McCallion - Rotunda HospitalPatrick J. McNamara - University of IowaAfif EL-Khuffash - Rotunda Hospital
- Resource Type
- Journal article
- Publication Details
- Early human development, Vol.153, pp.105291-105291
- Publisher
- Elsevier
- DOI
- 10.1016/j.earlhumdev.2020.105291
- PMID
- 33310351
- ISSN
- 0378-3782
- eISSN
- 1872-6232
- Number of pages
- 7
- Grant note
- RPAC 16-03 / Temple Street Foundation National Children's Research Centre
- Language
- English
- Date published
- 02/01/2021
- Academic Unit
- Stead Family Department of Pediatrics; Neonatology; Internal Medicine
- Record Identifier
- 9984353882002771
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