Journal article
The improved success rate and reduced complications of a novel localization device vs. hookwire for thoracoscopic resection of small pulmonary nodules: a single-center, open-label, randomized clinical trial
Translational lung cancer research, Vol.11(8), pp.1702-1712
08/01/2022
DOI: 10.21037/tlcr-22-555
PMCID: PMC9459612
PMID: 36090631
Abstract
Background: In our previous study, we developed a 4-hook claw-suture localization device for pulmonary nodule resection, which acheived satifisfactory results. Following this, we conducted this single-center, open-label, randomized clinical trial to compare the success rate and complication rate of this novel localization device and currently widely-used hookwire.
Methods: Patients with small pulmonary nodules (0.4–1 cm) who received preoperative localization and thoracoscopic resection at Shanghai Chest Hospital were randomly assigned (1:2 ratio, via computer-generated randomized numbers) to undergo localization using either a novel claw-suture system (claw group) or classical (hookwire group) localization device. The primary endpoint of this study was localization success rate, and the secondary endpoints included complications, localization-related time, and pain.
Results: A total of 411 patients were randomly assigned to the claw group (n=136) or the hookwire group (n=275) before thoracoscopic resection of small pulmonary nodules and analyzed. Compared with the hookwire group, the claw group had a significantly higher success rate (133/136, 97.8% vs. 254/275, 92.4%, P=0.027), less asymptomatic hemorrhage (16.9% vs. 37.5%, P=0.003) and pleural reaction (0% vs. 5.1%, P=0.017), as well as better pain alleviation 10 min after localization (measured using the difference between two visual analog scale scores, 0.84±0.98 vs. 0.35±0.79, P<0.001). In contrast, the hookwire group was associated with a shorter localization procedure duration than the claw group (7.2±2.9 vs. 14.4±6.6 min, P<0.001). In the multiple localization subgroup, the claw group compared to the hookwire group also achieved higher success (32/33, 97.0% vs. 70/86, 81.4%) and less pleural reaction (0% vs. 16.3%).
Conclusions: The new claw-suture localization device is superior to traditional hookwire, with a higher success rate, fewer complications, and better patient tolerance for preoperative localization of small pulmonary nodules.
Details
- Title: Subtitle
- The improved success rate and reduced complications of a novel localization device vs. hookwire for thoracoscopic resection of small pulmonary nodules: a single-center, open-label, randomized clinical trial
- Creators
- Liwen Fan - Department of Thoracic Surgery, Shanghai Chest Hospital Shanghai Jiao Tong UniversityWenyan Ma - Clinical Research Center, Shanghai Chest Hospital Shanghai Jiao Tong UniversityJie Ma - Department of Thoracic Surgery Anhui Chest HospitalLongtang Yang - Department of RadiologyZhexin Wang - Shanghai Jiao Tong UniversityKe Xu - Department of Thoracic Surgery, Shanghai Chest Hospital Shanghai Jiao Tong UniversityYunxuan Jia - Department of Thoracic Surgery, Shanghai Chest Hospital Shanghai Jiao Tong UniversityBeibei Sun - Institute for Thoracic Oncology, Shanghai Chest Hospital Shanghai Jiao Tong UniversityJessica C. Sieren - University of IowaHaitang Yang - Shanghai Jiao Tong UniversityFeng Yao - Department of Thoracic Surgery, Shanghai Chest Hospital Shanghai Jiao Tong University
- Resource Type
- Journal article
- Publication Details
- Translational lung cancer research, Vol.11(8), pp.1702-1712
- DOI
- 10.21037/tlcr-22-555
- PMID
- 36090631
- PMCID
- PMC9459612
- NLM abbreviation
- Transl Lung Cancer Res
- ISSN
- 2218-6751
- eISSN
- 2226-4477
- Publisher
- AME Publishing Company
- Language
- English
- Date published
- 08/01/2022
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology
- Record Identifier
- 9984318696902771
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