The independent effect of pain in one versus two knees on the presence of low physical function in a multicenter knee osteoarthritis study

Daniel K White; Yuqing Zhang; David T Felson; Jingbo Niu; Julie J Keysor; Michael C Nevitt; Cora E Lewis; James C Torner; Tuhina Neogi

doi:10.1002/acr.20166

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The independent effect of pain in one versus two knees on the presence of low physical function in a multicenter knee osteoarthritis study

Journal article

Open access

Peer reviewed

The independent effect of pain in one versus two knees on the presence of low physical function in a multicenter knee osteoarthritis study

Daniel K White, Yuqing Zhang, David T Felson, Jingbo Niu, Julie J Keysor, Michael C Nevitt, Cora E Lewis, James C Torner and Tuhina Neogi

Arthritis care & research (2010), Vol.62(7), pp.938-943

07/2010

DOI: 10.1002/acr.20166

PMCID: PMC2902715

PMID: 20191572

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Abstract

Although knee pain severity is thought to greatly impact function, the additional contribution of pain in 1 versus 2 knees is not known. We examined the relationship between unilateral versus bilateral pain with low physical functioning at baseline and 30 months while accounting for knee pain severity. The Multicenter Osteoarthritis Study is a cohort study of people who have or are at high risk for knee osteoarthritis. We defined low physical function as Western Ontario and McMaster Universities Osteoarthritis Index physical functioning scores > or = 28 of 68, consistent with poor functional outcome. Incidence and improvement from low physical function were defined as scores that declined below and improved above this threshold at 30 months. We examined the association between pain in 1 or 2 knees with low physical function with risk ratios (RRs) adjusting for known confounders. Of the 2,069 subjects (mean +/- SD age 63 +/- 8 years, mean +/- SD body mass index 31 +/- 6 kg/m(2), 63% women), the prevalence of low physical functioning was 50% lower among persons with unilateral pain compared with those with bilateral pain (adjusted prevalence ratio 0.5 [95% confidence interval (95% CI) 0.3-0.7]). Of those without low physical functioning at baseline, the risk of incidence at 30 months was 30% less for unilateral compared with bilateral pain (adjusted RR 0.7 [95% CI 0.5-1.0]). Of those with low physical functioning at baseline, improvement was 1.7 times more likely for those with unilateral compared with bilateral pain (adjusted RR 1.7 [95% CI 1.3-2.2]). The presence of pain in 1 versus 2 knees provides important information regarding present and future physical functioning.

Disability Evaluation

Follow-Up Studies

Pain - epidemiology

Humans

Middle Aged

Male

Risk

Osteoarthritis, Knee - epidemiology

Disease Progression

Incidence

Osteoarthritis, Knee - complications

Pain - etiology

Female

Aged

Pain Measurement

Details

Title: Subtitle: The independent effect of pain in one versus two knees on the presence of low physical function in a multicenter knee osteoarthritis study
Creators: Daniel K White - Boston University School of Medicine, Boston, Massachusetts, USA. white.daniel@gmail.com
Yuqing Zhang
David T Felson
Jingbo Niu
Julie J Keysor
Michael C Nevitt
Cora E Lewis
James C Torner
Tuhina Neogi
Resource Type: Journal article
Publication Details: Arthritis care & research (2010), Vol.62(7), pp.938-943
DOI: 10.1002/acr.20166
PMID: 20191572
PMCID: PMC2902715
NLM abbreviation: Arthritis Care Res (Hoboken)
ISSN: 1529-0131
eISSN: 2151-4658
Publisher: United States
Grant note: U01 AG018947 / NIA NIH HHS U01 AG019069-01A1 / NIA NIH HHS U01 AG018832 / NIA NIH HHS AR007598 / NIAMS NIH HHS U01 AG019069 / NIA NIH HHS U01-AG18947 / NIA NIH HHS AR47885 / NIAMS NIH HHS P60 AR047785 / NIAMS NIH HHS U01 AG018820-01A1 / NIA NIH HHS U01-AG18832 / NIA NIH HHS K23 AR055127-01 / NIAMS NIH HHS K23-AR055127 / NIAMS NIH HHS K23 AR055127 / NIAMS NIH HHS T32 AR007598 / NIAMS NIH HHS U01 AG018832-01A1 / NIA NIH HHS U01-AG19069 / NIA NIH HHS U01-AG18820 / NIA NIH HHS U01 AG018947-01A1 / NIA NIH HHS U01 AG018820 / NIA NIH HHS
Language: English
Date published: 07/2010
Academic Unit: Epidemiology; Surgery; Injury Prevention Research Center; Neurosurgery
Record Identifier: 9983996093602771

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