Journal article
The indirect effect of Tityus discrepans on rabbit pulmonary vasculature
Respiratory physiology & neurobiology, Vol.134(1), pp.33-41
2003
DOI: 10.1016/S1569-9048(02)00201-X
PMID: 12573879
Abstract
Serum (IS) was obtained 0.5, 2, 4 or 6 h after inoculating s.c. six rabbits (≈2 kg) in each time period with 1 mg/kg of
Tityus
discrepans (Td) venom; the control was serum obtained from four rabbits 4 h after injecting them 1 ml s.c. of 0.9% NaCl. IS produced a transient (<25 min) rise in pulmonary artery pressure of isolated and perfused rabbit lungs, other lung parameters were not altered. We found that both scorpion venom and IS produced a ≈50% transient increase of transendothelial electric resistance in cultured tissue human umbilical cord vein. Neither venom nor IS changed the transepithelial electrical resistance of tissue cultured human airway epithelia. The experiments suggest that humoral factors contained in the inoculated serum modify vascular endothelium in a much more effective manner than the venom by itself. These experiments also make it unlikely that vascular endothelium is the source of the humoral factors contained in inflammatory serum.
Details
- Title: Subtitle
- The indirect effect of Tityus discrepans on rabbit pulmonary vasculature
- Creators
- Eva Novoa - Unit Of Respiration Physiology, Instituto de Medicina Experimental, Facultad de Medicina, Escuela Luis Razetti, Universidad Central de Venezuela (UCV), Apartado 50587, Caracas 1050, VenezuelaGina D'Suze - Laboratory of Cellular Neuropharmacology, Centro de Biofı́sica y Bioquı́mica, Instituto Venezolano de Investigaciones Cientı́ficas (IVIC), Apartado 21827, Caracas 1020-A, VenezuelaMichael Winter - Department of Internal Medicine, College of Medicine, University of Iowa, Iowa City, IA 52242, USAAstrid Crespo - Unit Of Respiration Physiology, Instituto de Medicina Experimental, Facultad de Medicina, Escuela Luis Razetti, Universidad Central de Venezuela (UCV), Apartado 50587, Caracas 1050, VenezuelaMaria A Tortoledo - Unit Of Respiration Physiology, Instituto de Medicina Experimental, Facultad de Medicina, Escuela Luis Razetti, Universidad Central de Venezuela (UCV), Apartado 50587, Caracas 1050, VenezuelaHéctor Marcano - Unit Of Respiration Physiology, Instituto de Medicina Experimental, Facultad de Medicina, Escuela Luis Razetti, Universidad Central de Venezuela (UCV), Apartado 50587, Caracas 1050, VenezuelaEliot Friedman - Unit Of Respiration Physiology, Instituto de Medicina Experimental, Facultad de Medicina, Escuela Luis Razetti, Universidad Central de Venezuela (UCV), Apartado 50587, Caracas 1050, VenezuelaCarlos Sevcik - Laboratory of Cellular Neuropharmacology, Centro de Biofı́sica y Bioquı́mica, Instituto Venezolano de Investigaciones Cientı́ficas (IVIC), Apartado 21827, Caracas 1020-A, VenezuelaJoseph Zabner - Department of Internal Medicine, College of Medicine, University of Iowa, Iowa City, IA 52242, USARoberto Sánchez de León - Unit Of Respiration Physiology, Instituto de Medicina Experimental, Facultad de Medicina, Escuela Luis Razetti, Universidad Central de Venezuela (UCV), Apartado 50587, Caracas 1050, Venezuela
- Resource Type
- Journal article
- Publication Details
- Respiratory physiology & neurobiology, Vol.134(1), pp.33-41
- Publisher
- Elsevier B.V
- DOI
- 10.1016/S1569-9048(02)00201-X
- PMID
- 12573879
- ISSN
- 1569-9048
- eISSN
- 1878-1519
- Language
- English
- Date published
- 2003
- Academic Unit
- Pulmonary, Critical Care, and Occupational Medicine; Anatomy and Cell Biology; Internal Medicine
- Record Identifier
- 9984094491402771
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