Journal article
The influence of aspirin on the course of induced midtrimester abortion
American journal of obstetrics and gynecology, Vol.124(6), pp.607-610
03/15/1976
DOI: 10.1016/0002-9378(76)90062-4
PMID: 769555
Abstract
Prostaglandins appear to mediate the uterine contractions of abortion and labor, and aspirin has been shown to be an inhibitor of prostaglandin synthesis. In this double-blind, placebo-controlled, prospective, and randomized study, aspirin was administered orally in doses of 600 mg. every 6 hours to patients undergoing induced midtrimester abortions with hyperosmolar urea and oxytocin augmentation. The mean injection-abortion interval was significantly prolonged by aspirin in nulliparous patients (aspirin 32.3 +/- 3.3 hr. vs. placebo 21.5 +/- 3.5 hr.) and no aspirin-treated nullipara aborted in less than 18 hours. There was no significant difference between treatment groups in the mean injection-abortion interval in the multiparous patients at the dose of aspirin used. The effectiveness of aspirin in the prolongation of the injection-abortion interval has potential therapeutic implications for the treatment of premature labor.
Details
- Title: Subtitle
- The influence of aspirin on the course of induced midtrimester abortion
- Creators
- Jennifer R Niebyl - University of Iowa, Obstetrics and GynecologyDavid A. BlakeLonnie S BurnettTheodore M King
- Resource Type
- Journal article
- Publication Details
- American journal of obstetrics and gynecology, Vol.124(6), pp.607-610
- Publisher
- United States
- DOI
- 10.1016/0002-9378(76)90062-4
- PMID
- 769555
- ISSN
- 0002-9378
- eISSN
- 1097-6868
- Language
- English
- Date published
- 03/15/1976
- Academic Unit
- Obstetrics and Gynecology
- Record Identifier
- 9983557402502771
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