Journal article
The influence of exercise training on inflammatory cytokines and C-reactive protein
Medicine and science in sports and exercise, Vol.39(10), pp.1714-1719
2007
DOI: 10.1249/mss.0b013e31811ece1c
PMID: 17909397
Abstract
PURPOSE: The purpose of this study was to examine the influence of a 12-wk exercise training program on inflammatory cytokine and C-reactive protein (CRP) concentrations. A secondary purpose was to determine whether training-induced changes in cytokines and CRP were influenced by age. METHODS: Twenty-nine younger (18-35 yr) and 31 older (65-85 yr) subjects were assigned to young physically active (YPA, N = 15; 25 ± 5 yr), young physically inactive (YPI, N= 14; 25 ± 4.7 yr), old physically active (OPA, N = 14; 71 ± 4 yr), or old physically inactive (OPI, N = 17; 71 ± 4 yr) groups. The inactive groups completed 12 wk (3 d•wk) of aerobic and resistance exercises, and the physically active control groups continued their normal exercise programs. Blood samples were collected before and after the 12-wk period, and the concentrations of serum CRP, plasma interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and interleukin-1 beta (IL-1β) were determined using separate ELISA. RESULTS: Control (YPA and OPA) estimated V̇O2max was unchanged. Exercise training increased estimated V̇O2max an average of 10.4% and increased strength by an average of 38.1% in both PI groups. Serum CRP decreased with training (YPI and OPI) groups and was not different from the YPA and OPA groups after training. Plasma IL-6 and IL-1β did not change, whereas TNF-α was higher than YPI and YPA at baseline and after the intervention period. CONCLUSION: These results support the use of combined aerobic/resistance training as a modality to reduce the risk of cardiovascular disease development as defined by a decrease in serum CRP concentration in healthy humans. ©2007The American College of Sports Medicine.
Details
- Title: Subtitle
- The influence of exercise training on inflammatory cytokines and C-reactive protein
- Creators
- Laura K Stewart - Louisiana State UniversityMichael G Flynn - Purdue University West LafayetteWayne W Campbell - Purdue University West LafayetteBruce A Craig - Purdue University West LafayetteJ. Paul Robinson - Purdue University West LafayetteKyle L Timmerman - Purdue University West LafayetteBrian K Mcfarlin - University of HoustonPaul M Coen - Purdue University West LafayetteErin Talbert - Purdue University West Lafayette
- Resource Type
- Journal article
- Publication Details
- Medicine and science in sports and exercise, Vol.39(10), pp.1714-1719
- Publisher
- Lippincott Williams & Wilkins
- DOI
- 10.1249/mss.0b013e31811ece1c
- PMID
- 17909397
- ISSN
- 0195-9131
- eISSN
- 1530-0315
- Language
- English
- Date published
- 2007
- Academic Unit
- Fraternal Order of Eagles Diabetes Research Center; Health and Human Physiology; Internal Medicine
- Record Identifier
- 9984259642002771
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