Journal article
The influence of maternal disease on metabolites measured as part of newborn screening
The Journal of Maternal-Fetal & Neonatal Medicine, Vol.26(14), pp.1380-1383
09/01/2013
DOI: 10.3109/14767058.2013.791267
PMCID: PMC3753672
PMID: 23550828
Abstract
Objective: Measurements of neonatal metabolites are commonly used in newborn screening (NBS) programs to detect inborn errors of metabolism. Variation in these metabolites, particularly in infants born preterm (<37 weeks gestation), can result from multiple etiologies. We sought to evaluate the impact of maternal complications of pregnancy and environmental stressors on NBS metabolites.
Methods: We examined 49 metabolic biomarkers obtained from routine NBS in 452 infants born preterm for association with maternal environmental stressors and complications of pregnancy.
Results: Neonatal free carnitine (C0, p = 1.4 × 10
−7
), acetylcarnitine (C2, p = 2.7 × 10
−7
), octenoylcarnitine (C8:1, p = 5.2 × 10
−11
) and linoleoylcarnitine (C18:2, p = 9.1 × 10
−7
) were elevated in infants born to preeclamptic mothers. Similar elevations were observed in small for gestational age infants and in infants where labor was not initiated prior to delivery. When accounting for all three factors, associations remained strongest between acylcarnitines and preeclampsia.
Conclusion: We observed that maternal conditions, particularly preeclampsia, influence NBS biomarkers. This is important for identifying maternal conditions that influence metabolites measured during routine NBS that are also markers of fetal growth and overall health.
Details
- Title: Subtitle
- The influence of maternal disease on metabolites measured as part of newborn screening
- Creators
- Kelli K Ryckman - Department of PediatricsOleg A Shchelochkov - Division of Genetics, Department of PediatricsDaniel E Cook - Department of PediatricsStanton L Berberich - State Hygienic Laboratory, University of IowaSara Copeland - Genetics Services Branch, Maternal and Child Health Bureau, Health Resources and Services AdministrationJohn M Dagle - Department of PediatricsJeffrey C Murray - Department of Pediatrics
- Resource Type
- Journal article
- Publication Details
- The Journal of Maternal-Fetal & Neonatal Medicine, Vol.26(14), pp.1380-1383
- DOI
- 10.3109/14767058.2013.791267
- PMID
- 23550828
- PMCID
- PMC3753672
- NLM abbreviation
- J Matern Fetal Neonatal Med
- ISSN
- 1476-7058
- eISSN
- 1476-4954
- Publisher
- Taylor & Francis
- Language
- English
- Date published
- 09/01/2013
- Academic Unit
- Anatomy and Cell Biology; International Programs; Stead Family Department of Pediatrics; Epidemiology; Pediatric Dentistry; Craniofacial Anomalies Research Center; Nursing; Public Policy Center (Archive); Biochemistry and Molecular Biology; Dental Research; Neonatology
- Record Identifier
- 9983995125002771
Metrics
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