Journal article
The influence of mutations in the SLC26A4 gene on the temporal bone in a population with enlarged vestibular aqueduct
Archives of otolaryngology--head & neck surgery, Vol.133(2), pp.162-168
2007
DOI: 10.1001/archotol.133.2.162
PMID: 17309986
Abstract
Objective: To correlate genetic and audiometric findings with a detailed radiologic analysis of the temporal bone in patients with enlarged vestibular aqueduct (EVA) to ascertain the contribution of SLC26A4 gene mutations to this phenotype. Design: A retrospective review of patients with EVA identified in a database of pediatric hearing-impaired patients. Setting: A tertiary care pediatric referral center. Patients: Seventy-one children with EVA and screening results for SLC26A4 mutations. Main Outcome Measures: Genetic screening results, audiometric thresholds, and radiographic temporal bone measurements. Results: Seventy-one children with EVA were screened for SLC26A4 mutations. Mutations were found in 27% of children overall, while only 8% had biallelic mutations. The mean initial pure-tone average (PTA) was 59 dB; the mean final PTA was 67 dB. A bilateral EVA was found in 48 (67%) of the children; a unilateral EVA was found in 23 (33%). Progressive hearing loss (in at least 1 ear) was seen in 29 (41%) of the patients. The strongest genotype-phenotype interaction was seen in children with a bilateral EVA. Among children with SLC26A4 mutations, there was a significantly wider vestibular aqueduct at the midpoint and a wider vestibule width (P<.05) than in children without the mutation. Among patients with a bilateral EVA, children with any SLC26A4 mutation were more likely to have a more severe final PTA (64 dB vs 32 dB), larger midpoint measurement (2.1 vs 1.1 mm), and larger operculum measurement (3.0 vs 2.0 mm) than those without the mutation in their betterhearing ear (P<.05). Conclusions: In a population of pediatric patients with an EVA and hearing loss, SLC26A4 mutations are a contributor to the phenotype. Our data suggest that other genetic factors also have important contributions to this phenotype. The presence of an abnormal SLC26A4 allele, even in the heterozygous state, was associated with greater enlargement of the vestibular aqueduct, abnormal development of the vestibule, and possibly a stable hearing outcome. ©2007 American Medical Association. All rights reserved.
Details
- Title: Subtitle
- The influence of mutations in the SLC26A4 gene on the temporal bone in a population with enlarged vestibular aqueduct
- Creators
- Colm Madden - Manchester Royal InfirmaryMark Halsted - Cincinnati Children's Hospital Medical CenterRichard Smith - University of IowaDaniel Choo - University of CincinnatiJohn Greinwald - University of CincinnatiJareen MEINZEN-DERR - Cincinnati Children's Hospital Medical CenterDianna Bardo - University of ChicagoMark Boston - Cincinnati Children's Hospital Medical CenterEllis Arjmand - University of CincinnatiCarla Nishimura - University of IowaTAO Yang - University of IowaComing Benton - Cincinnati Children's Hospital Medical CenterVijay Das - Manchester Royal Infirmary
- Resource Type
- Journal article
- Publication Details
- Archives of otolaryngology--head & neck surgery, Vol.133(2), pp.162-168
- DOI
- 10.1001/archotol.133.2.162
- PMID
- 17309986
- NLM abbreviation
- Arch Otolaryngol Head Neck Surg
- ISSN
- 0886-4470
- eISSN
- 1538-361X
- Publisher
- American Medical Association
- Language
- English
- Date published
- 2007
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Molecular Physiology and Biophysics; Anatomy and Cell Biology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Otolaryngology; Internal Medicine
- Record Identifier
- 9984256836202771
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