Journal article
The influence of spray properties on intranasal deposition
Journal of aerosol medicine, Vol.20(4), pp.495-508
12/01/2007
DOI: 10.1089/jam.2007.0638
PMID: 18158721
Abstract
While numerous devices, formulations, and spray characteristics have been shown to influence nasal deposition efficiency, few studies have attempted to identify which of these interacting factors plays the greatest role in nasal spray deposition. The deposition patterns of solutions with a wide range of surface tensions and viscosities were measured using an MRI-derived nasal cavity replica. The resulting spray plumes had angles between 29 degrees and 80 degrees and contained droplet sizes (D-upsilon 50) from 37-157 mu m. Each formulation contained rhodamine 590 as a fluorescent marker for detection. Administration angles of 30 degrees, 40 degrees, or 50 degrees above horizontal were tested to investigate the role of user technique on nasal deposition. The amount of spray deposited within specific regions of the nasal cavity was determined by disassembling the replica and measuring the amount of rhodamine retained in each section. Most of the spray droplets were deposited onto the anterior region of the model, but sprays with small plume angles were capable of reaching the turbinate region with deposition efficiencies approaching 90%. Minimal dependence on droplet size, viscosity, or device was observed. Changes in inspiratory flow rate (0-60 L/min) had no significant effect on turbinate deposition efficiency. Both plume angle and administration angle were found to be important factors in determing deposition efficiency. For administration angles of 40 degrees or 50 degrees, maximal turbinate deposition efficiency (30-50%) occurred with plume angles of 55-65 degrees, whereas a 30 degrees administration angle gave an similar to 75% deposition efficiency for similar plume angles. Deposition efficiencies of similar to 90% could be achieved with plume angles <30 degrees using 30 degrees administration angles. Both the plume angle and administration angle are critical factors in determining deposition efficiency, while many other spray parameters, including particle size, have relatively minor influences on deposition within the nasal cavity.
Details
- Title: Subtitle
- The influence of spray properties on intranasal deposition
- Creators
- Mow Yee Foo - University of IowaYung-Sung Cheng - Lovelace Resp Res Inst, Albuquerque, NM USAWei-Chung Su - Lovelace Resp Res Inst, Albuquerque, NM USAMaureen D. Donovan - Univ Iowa, Coll Pharm, Iowa City, IA 52242 USA
- Resource Type
- Journal article
- Publication Details
- Journal of aerosol medicine, Vol.20(4), pp.495-508
- Publisher
- Mary Ann Liebert, Inc
- DOI
- 10.1089/jam.2007.0638
- PMID
- 18158721
- ISSN
- 0894-2684
- eISSN
- 1557-9026
- Number of pages
- 14
- Grant note
- R01 OH003900 / NIOSH CDC HHS R01OH003900 / NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH; United States Department of Health & Human Services; Centers for Disease Control & Prevention - USA; National Institute for Occupational Safety & Health (NIOSH)
- Language
- English
- Date published
- 12/01/2007
- Academic Unit
- Pharmaceutical Sciences and Experimental Therapeutics
- Record Identifier
- 9984365893902771
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