Journal article
The influences of glucagon, epinephrine and α- and β-adrenergic agents of glycogenolysis in isolated rabbit hepatocytes and perfused livers
Biochimica et biophysica acta. General subjects, Vol.674(3), pp.297-305
1981
DOI: 10.1016/0304-4165(81)90360-3
PMID: 6263353
Abstract
1.
1. Glucagon, epinephrine, norepinephrine, dibutyryl cyclic AMP, isoproterenol and phenylephrine each enhance glycogenolysis in isolated perfused rabbit livers and/or hepatocytes.
2.
2. Such enhancement by epinephrine, norepinephrine, isoproterenol and phenylephrine is eliminated by propranolol but unaltered by phentolamine, suggesting that stimulation of glycogenolysis by each of these agents involves β-adrenergic-mediated mechanism(s).
3.
3. Data obtained with hepatocytes from 16–20-week-old rabbits and from 7–8-week-old rabbits are identical as far as enhancement of glycogenolysis by β-adrenergic stimulation is concerned, implying that the nature of functional adrenergic receptors in rabbit liver does not change during the process of maturation.
Details
- Title: Subtitle
- The influences of glucagon, epinephrine and α- and β-adrenergic agents of glycogenolysis in isolated rabbit hepatocytes and perfused livers
- Creators
- Gerald A RufoMark A YorekPaul D Ray
- Resource Type
- Journal article
- Publication Details
- Biochimica et biophysica acta. General subjects, Vol.674(3), pp.297-305
- Publisher
- Elsevier B.V
- DOI
- 10.1016/0304-4165(81)90360-3
- PMID
- 6263353
- ISSN
- 0304-4165
- eISSN
- 1872-8006
- Language
- English
- Date published
- 1981
- Academic Unit
- Fraternal Order of Eagles Diabetes Research Center; Endocrinology and Metabolism; Internal Medicine
- Record Identifier
- 9984094727202771
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