Journal article
The infralimbic cortex regulates the consolidation of extinction after cocaine self-administration
Learning & memory (Cold Spring Harbor, N.Y.), Vol.17(4), pp.168-175
04/2010
DOI: 10.1101/lm.1576810
PMCID: PMC2852618
PMID: 20332188
Abstract
The infralimbic cortex (IL) regulates the consolidation of extinction learning for fear conditioning. Whether the IL influences the consolidation of extinction learning for cocaine self-administration is unknown. To address this issue, male Sprague-Dawley rats underwent 2 wk of cocaine self-administration followed by extinction training. On the first 5 d of extinction, rats underwent brief (15- or 30-min) extinction sessions and received intra-IL microinjections immediately after each extinction session. On days 6-12 of extinction, rats underwent full-length (2-h) extinction sessions that were used to assess the retention of the extinction learning from the short sessions. IL inactivation via microinjections of the GABA agonists baclofen and muscimol (BM) immediately after the extinction sessions (days 1-5) impaired the retention of extinction learning. Control experiments demonstrated that this effect was not due to inactivation of the prelimbic cortex or due to effects of the drugs on the subsequent day's behavior. In contrast, post-training intra-IL microinjections of the allosteric AMPA receptor potentiator 4-[2-(phenylsulfonylamino)ethylthio]-2,6-difluorophenoxyacetamide (PEPA) enhanced retention of the extinction learning. As evidence suggests a role for the beta-adrenergic receptors in memory consolidation, other rats received microinjections of the beta(2)-adrenergic receptor agonist clenbuterol or antagonist ICI-118,551 (ICI). Post-training intra-IL administration of clenbuterol or pre-training administration of ICI enhanced or impaired, respectively, the retention of extinction learning. These data indicate that the IL, and specifically the glutamatergic and beta-adrenergic systems in the IL, regulates the consolidation of extinction of cocaine self-administration and that the IL can be manipulated to influence the retention of extinction.
Details
- Title: Subtitle
- The infralimbic cortex regulates the consolidation of extinction after cocaine self-administration
- Creators
- Ryan T LaLumiere - Neurobiology of Addiction Research Center, Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA. lalumie@musc.eduKate E NiehoffPeter W Kalivas
- Resource Type
- Journal article
- Publication Details
- Learning & memory (Cold Spring Harbor, N.Y.), Vol.17(4), pp.168-175
- Publisher
- United States
- DOI
- 10.1101/lm.1576810
- PMID
- 20332188
- PMCID
- PMC2852618
- ISSN
- 1072-0502
- eISSN
- 1549-5485
- Grant note
- DA12513 / NIDA NIH HHS R01 DA012513 / NIDA NIH HHS DA027055 / NIDA NIH HHS P50 DA015369 / NIDA NIH HHS DA015369 / NIDA NIH HHS R21 DA027055 / NIDA NIH HHS
- Language
- English
- Date published
- 04/2010
- Academic Unit
- Psychological and Brain Sciences; Iowa Neuroscience Institute
- Record Identifier
- 9984070153902771
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