The inhibitory effect of MI paste, fluoride and a combination of both on the progression of artificial caries-like lesions in enamel

Maria Teresa Pulido; James S Wefel; Maria Marcela Hernandez; Gerald E Denehy; Sandra Guzman-Armstrong; Jane M Chalmers; Fang Qian

doi:10.2341/07-136

Back

The inhibitory effect of MI paste, fluoride and a combination of both on the progression of artificial caries-like lesions in enamel

Journal article

Peer reviewed

The inhibitory effect of MI paste, fluoride and a combination of both on the progression of artificial caries-like lesions in enamel

Maria Teresa Pulido, James S Wefel, Maria Marcela Hernandez, Gerald E Denehy, Sandra Guzman-Armstrong, Jane M Chalmers and Fang Qian

Operative dentistry, Vol.33(5), pp.550-555

09/2008

DOI: 10.2341/07-136

PMID: 18833861

View Online

Abstract

This in-vitro study evaluated the inhibition of demineralization in enamel sections produced by MI paste, fluoride and a combination of both, compared to artificial saliva and NaF 5000 ppm in a caries progression pH-cycling model. Twenty-one teeth were demineralized to create subsurface enamel lesions (approximately 200 microns in depth). The teeth were sectioned and characterized using polarized-light-microscopy (PLM). A single section from each lesion was assigned to a treatment group: Artificial saliva, NaF 5000 ppm (Prevident, Colgate), MI paste (Recaldent, GC America Inc), NaF 1100 ppm (Crest, Procter & Gamble) and NaF 1100 ppm plus MI paste. The sections were covered with varnish except for an exposed window on the external surface of the lesion and placed in a six-day pH-cycling model with two daily treatment applications of two minutes each. The sections were characterized by PLM, and the lesion areas were measured using a digital image analysis system. Based on a paired-sample t-test, significant differences (p < .05) in percentage of change in lesion size were found between the high fluoride group and all the other groups. No significant difference was found between the artificial saliva and MI paste group, neither was there any significant difference between the NaF 1100 ppm, the combined application group or the MI paste group alone. In conclusion, the higher concentration of NaF (5000 ppm) reduced lesion progression to the greatest extent. The MI paste group did not show any effect on the inhibition of lesion progression. Further studies on the preventive effect and longer treatment applications are recommended.

Sodium Fluoride - administration & dosage

Saliva, Artificial - administration & dosage

Cariostatic Agents - therapeutic use

Humans

Microscopy, Polarization

Cariostatic Agents - administration & dosage

Disease Progression

Caseins - administration & dosage

Tooth Demineralization - prevention & control

Caseins - therapeutic use

Image Processing, Computer-Assisted

Placebos

Dental Caries - prevention & control

Dental Enamel - drug effects

Drug Combinations

Sodium Fluoride - therapeutic use

Toothpastes - therapeutic use

Dental Caries - physiopathology

Hydrogen-Ion Concentration

Details

Title: Subtitle: The inhibitory effect of MI paste, fluoride and a combination of both on the progression of artificial caries-like lesions in enamel
Creators: Maria Teresa Pulido - Department of Restorative and Prosthetic Dentistry, College of Dentistry, The Ohio State University, Columbus, OH, USA. pulido.6@osu.edu
James S Wefel
Maria Marcela Hernandez
Gerald E Denehy
Sandra Guzman-Armstrong
Jane M Chalmers
Fang Qian
Resource Type: Journal article
Publication Details: Operative dentistry, Vol.33(5), pp.550-555
Publisher: United States
DOI: 10.2341/07-136
PMID: 18833861
ISSN: 0361-7734
eISSN: 1559-2863
Language: English
Date published: 09/2008
Academic Unit: Preventive and Community Dentistry; Operative Dentistry; Family Dentistry; Dental Research
Record Identifier: 9984065809202771

Metrics

25 Record Views

50 Times Cited - Web of Science