Journal article
The innate immune function of airway epithelial cells in inflammatory lung disease
The European respiratory journal, Vol.45(4), pp.1150-1162
04/2015
DOI: 10.1183/09031936.00141514
PMCID: PMC4719567
PMID: 25700381
Abstract
The airway epithelium is now considered to be central to the orchestration of pulmonary inflammatory and immune responses, and is also key to tissue remodelling. It acts as the first barrier in the defence against a wide range of inhaled challenges, and is critically involved in the regulation of both innate and adaptive immune responses to these challenges. Recent progress in our understanding of the developmental regulation of this tissue, the differentiation pathways, recognition of pathogens and antimicrobial responses is now exploited to help understand how epithelial cell function and dysfunction contributes to the pathogenesis of a variety of inflammatory lung diseases. Herein, advances in our knowledge of the biology of airway epithelium, as well as its role and (dys)function in asthma, chronic obstructive pulmonary fibrosis and cystic fibrosis will be discussed.
Details
- Title: Subtitle
- The innate immune function of airway epithelial cells in inflammatory lung disease
- Creators
- Pieter S Hiemstra - Dept of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands. p.s.hiemstra@lumc.nlPaul B McCray Jr - Dept of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, IA, USARobert Bals - Dept of Internal Medicine V - Pulmonology, Allergology and Critical Care Medicine, Saarland University, Homburg, Germany
- Resource Type
- Journal article
- Publication Details
- The European respiratory journal, Vol.45(4), pp.1150-1162
- DOI
- 10.1183/09031936.00141514
- PMID
- 25700381
- PMCID
- PMC4719567
- ISSN
- 0903-1936
- eISSN
- 1399-3003
- Grant note
- HL-51670 / NHLBI NIH HHS P30 ES005605 / NIEHS NIH HHS P01 HL091842 / NHLBI NIH HHS HL-091842 / NHLBI NIH HHS HL-118000 / NHLBI NIH HHS R01 HL118000 / NHLBI NIH HHS P01 HL051670 / NHLBI NIH HHS P30 DK054759 / NIDDK NIH HHS
- Language
- English
- Date published
- 04/2015
- Academic Unit
- Microbiology and Immunology; Pulmonary Medicine; Stead Family Department of Pediatrics; Internal Medicine
- Record Identifier
- 9984093366002771
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