Journal article
The insula: a critical neural substrate for craving and drug seeking under conflict and risk
Annals of the New York Academy of Sciences, Vol.1316(1), pp.53-70
05/2014
DOI: 10.1111/nyas.12415
PMCID: PMC4114146
PMID: 24690001
Abstract
Drug addiction is characterized by the inability to control drug use when it results in negative consequences or conflicts with more adaptive goals. Our previous work showed that damage to the insula disrupted addiction to cigarette smoking—the first time that the insula was shown to be a critical neural substrate for addiction. Here, we review those findings, as well as more recent studies that corroborate and extend them, demonstrating the role of the insula in (1) incentive motivational processes that drive addictive behavior, (2) control processes that moderate or inhibit addictive behavior, and (3) interoceptive processes that represent bodily states associated with drug use. We then describe a theoretical framework that attempts to integrate these seemingly disparate findings. In this framework, the insula functions in the recall of interoceptive drug effects during craving and drug seeking under specific conditions where drug taking is perceived as risky and/or where there is conflict between drug taking and more adaptive goals. We describe this framework in an evolutionary context and discuss its implications for understanding the mechanisms of behavior change in addiction treatments.
Details
- Title: Subtitle
- The insula: a critical neural substrate for craving and drug seeking under conflict and risk
- Creators
- Nasir H Naqvi - Brain and Creativity Institute and Department of Psychology, University of Southern California, Los Angeles, CaliforniaNatassia Gaznick - Brain and Creativity Institute and Department of Psychology, University of Southern California, Los Angeles, CaliforniaDaniel Tranel - Brain and Creativity Institute and Department of Psychology, University of Southern California, Los Angeles, CaliforniaAntoine Bechara - Brain and Creativity Institute and Department of Psychology, University of Southern California, Los Angeles, California
- Resource Type
- Journal article
- Publication Details
- Annals of the New York Academy of Sciences, Vol.1316(1), pp.53-70
- DOI
- 10.1111/nyas.12415
- PMID
- 24690001
- PMCID
- PMC4114146
- NLM abbreviation
- Ann N Y Acad Sci
- ISSN
- 0077-8923
- eISSN
- 1749-6632
- Publisher
- Wiley
- Grant note
- name: NIDA, award: R01 DA16708, T32 DA007294; DOI: 10.13039/100007027, name: Leon Levy Foundation
- Language
- English
- Date published
- 05/2014
- Academic Unit
- Neurology; Psychological and Brain Sciences; Iowa Neuroscience Institute
- Record Identifier
- 9984002335002771
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