The intensity of continuous theta burst stimulation, but not the waveform used to elicit motor evoked potentials, influences its outcome in the human motor cortex

Takuya Sasaki; Satoshi Kodama; Naohiko Togashi; Yuichiro Shirota; Yusuke Sugiyama; Shin ichi Tokushige; Satomi Inomata-Terada; Yasuo Terao; Yoshikazu Ugawa; Masashi Hamada

doi:10.1016/j.brs.2017.12.003

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The intensity of continuous theta burst stimulation, but not the waveform used to elicit motor evoked potentials, influences its outcome in the human motor cortex

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The intensity of continuous theta burst stimulation, but not the waveform used to elicit motor evoked potentials, influences its outcome in the human motor cortex

Takuya Sasaki, Satoshi Kodama, Naohiko Togashi, Yuichiro Shirota, Yusuke Sugiyama, Shin ichi Tokushige, Satomi Inomata-Terada, Yasuo Terao, Yoshikazu Ugawa and Masashi Hamada

Brain stimulation, Vol.11(2), pp.400-410

03/01/2018

DOI: 10.1016/j.brs.2017.12.003

PMID: 29258807

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Abstract

Background: Responses to continuous theta burst stimulation (cTBS) applied to the human primary motor cortex are highly variable between individuals. However, little is known about how to improve the after-effects of cTBS by adjusting the protocol characteristics. Objective: We examined whether current directions adopted in the measurement of cortical motor excitability indexed as motor evoked potentials (MEPs) affect the responses to cTBS. We also tested whether the stimulus intensity of cTBS influences the after-effects. Methods: Thirty-one healthy volunteers participated. The after-effects of cTBS with the conventional intensity of 80% of individual active motor threshold (AMT) (cTBS ) were tested by measuring MEP amplitudes induced by not only posterior-anterior (PA) but also anterior-posterior (AP) and biphasic (PA-AP) currents. We also investigated cTBS with 65% AMT (cTBS ) and 100% AMT (cTBS ) in subjects who showed depression of MEP amplitudes after cTBS , as well as cTBS in subjects in whom facilitation of MEPs was induced by cTBS Results: Current directions in MEP measurement had no influence on the cTBS responses. In subjects whose MEPs were depressed by cTBS , cTBS partly induced MEP facilitation, while cTBS abolished the after-effects. In subjects who showed MEP facilitation by cTBS , cTBS partly induced MEP depression. Conclusions: Stimulus intensity of cTBS influenced the responses to cTBS, and lowering stimulus intensity induced the expected after-effects of cTBS in some subjects.

Continuous theta burst stimulation (cTBS)

Motor cortex

Plasticity

Transcranial magnetic stimulation (TMS)

Variability

Details

Title: Subtitle: The intensity of continuous theta burst stimulation, but not the waveform used to elicit motor evoked potentials, influences its outcome in the human motor cortex
Creators: Takuya Sasaki - The University of Tokyo
Satoshi Kodama - The University of Tokyo
Naohiko Togashi - The University of Tokyo
Yuichiro Shirota - The University of Tokyo
Yusuke Sugiyama - The University of Tokyo
Shin ichi Tokushige - Kyorin University
Satomi Inomata-Terada - Kyorin University
Yasuo Terao - Kyorin University
Yoshikazu Ugawa - Fukushima Medical University
Masashi Hamada - The University of Tokyo
Resource Type: Journal article
Publication Details: Brain stimulation, Vol.11(2), pp.400-410
DOI: 10.1016/j.brs.2017.12.003
PMID: 29258807
ISSN: 1935-861X
eISSN: 1876-4754
Number of pages: 11
Grant note: 15H05881 / Japan Society for the Promotion of Science London (501100000646) 15H01658 / Japan Society for the Promotion of Science London (501100000646) 15K19476 / Japan Society for the Promotion of Science London (501100000646) 16H01605 / Japan Society for the Promotion of Science London (501100000646) 16H05322 / Japan Society for the Promotion of Science London (501100000646) Japan Society for the Promotion of Science (http://data.elsevier.com/vocabulary/SciValFunders/501100001691) 15H01658; 15H05881; 15K19476; 16H01605; 16H05322; 18K07521 / Japan Society for the Promotion of Science (http://data.elsevier.com/vocabulary/SciValFunders/501100001691)
Language: English
Date published: 03/01/2018
Academic Unit: Neurology
Record Identifier: 9985177941402771

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