Journal article
The interaction among donor characteristics, severity of liver disease, and the cost of liver transplantation
Liver transplantation, Vol.17(3), pp.233-242
03/2011
DOI: 10.1002/lt.22230
PMCID: PMC4447593
PMID: 21384505
Abstract
Accurate assessment of the impact of donor quality on liver transplant (LT) costs has been limited by the lack of a large, multicenter study of detailed clinical and economic data. A novel, retrospective database linking information from the University HealthSystem Consortium and the Organ Procurement and Transplantation Network registry was analyzed using multivariate regression to determine the relationship between donor quality (assessed through the Donor Risk Index [DRI]), recipient illness severity, and total inpatient costs (transplant and all readmissions) for 1 year following LT. Cost data were available for 9059 LT recipients. Increasing MELD score, higher DRI, simultaneous liver-kidney transplant, female sex, and prior liver transplant were associated with increasing cost of LT (P < 0.05). MELD and DRI interact to synergistically increase the cost of LT (P < 0.05). Donors in the highest DRI quartile added close to $12,000 to the cost of transplantation and nearly $22,000 to posttransplant costs in comparison to the lowest risk donors. Among the individual components of the DRI, donation after cardiac death (increased costs by $20,769 versus brain dead donors) had the greatest impact on transplant costs. Overall, 1-year costs were increased in older donors, minority donors, nationally shared organs, and those with cold ischemic times of 7-13 hours (P < 0.05 for all). In conclusion, donor quality, as measured by the DRI, is an independent predictor of LT costs in the perioperative and postoperative periods. Centers in highly competitive regions that perform transplantation on higher MELD patients with high DRI livers may be particularly affected by the synergistic impact of these factors.
Details
- Title: Subtitle
- The interaction among donor characteristics, severity of liver disease, and the cost of liver transplantation
- Creators
- Paolo R Salvalaggio - University of WashingtonNino Dzebisashvili - Saint Louis UniversityKara E MacLeod - University of WashingtonKrista L LentineAdrian Gheorghian - Saint Louis UniversityMark A Schnitzler - Saint Louis UniversitySamuel Hohmann - University HealthSystem ConsortiumDorry L Segev - Saint Louis UniversitySommer E Gentry - United States Naval AcademyDavid A Axelrod - Dartmouth–Hitchcock Medical Center
- Resource Type
- Journal article
- Publication Details
- Liver transplantation, Vol.17(3), pp.233-242
- DOI
- 10.1002/lt.22230
- PMID
- 21384505
- PMCID
- PMC4447593
- ISSN
- 1527-6465
- eISSN
- 1527-6473
- Grant note
- K08DK073036 / NIDDK NIH HHS RC1 DK086450 / NIDDK NIH HHS RC1 DK086450-02 / NIDDK NIH HHS K08 DK073036 / NIDDK NIH HHS 1RC1DK086450 / NIDDK NIH HHS
- Language
- English
- Date published
- 03/2011
- Academic Unit
- Surgery
- Record Identifier
- 9984321863602771
Metrics
26 Record Views