Journal article
The interrelationships of glycemic control measures: HbA1c, glycated albumin, fructosamine, 1,5-anhydroglucitrol, and continuous glucose monitoring
Pediatric diabetes, Vol.12(8), pp.690-695
12/01/2011
DOI: 10.1111/j.1399-5448.2011.00764.x
PMCID: PMC3193556
PMID: 21496193
Abstract
Objectives: To describe the interrelationships of glycemic control measures: hemoglobin A1c (HbA1c), glycated albumin, fructosamine, 1,5-anhydroglucitrol (1,5-AG), and continuous glucose monitoring (CGM) in children and adolescents with type 1 diabetes.
Methods: In total, 26 subjects of age 4-17 had HbA1c measurement followed within 14 d by three laboratory measures of glycemia and the collection of CGM glucose data (N = 21).
Results: Glycated albumin and fructosamine levels had a higher correlation with each other than with HbA1c. The correlation of 1,5-AG with HbA1c was lower (absolute r value = 0.25). All four measures had a similar degree of correlation with CGM-measured mean glucose (absolute r value = 0.50-0.56) and with hyperglycemic area under the curve (AUC) at 180 mg/ dL (0.50-0.60).
Conclusion: Each of the four measures (i. e., HbA1c, glycated albumin, fructosamine, and 1,5-AG) had a similar correlation with mean glucose and hyperglycemic AUC-180. 1,5-AG did not correlate with hyperglycemic AUC-180 better than did HbA1c.
Details
- Title: Subtitle
- The interrelationships of glycemic control measures: HbA1c, glycated albumin, fructosamine, 1,5-anhydroglucitrol, and continuous glucose monitoring
- Creators
- Roy Beck - Jaeb Center for Health ResearchMichael Steffes - University of MinnesotaDongyuan Xing - Jaeb Center for Health ResearchKatrina Ruedy - Jaeb Center for Health ResearchNelly Mauras - Nemours Children’s ClinicDarrell M. Wilson - Stanford UniversityCraig Kollman - Jaeb Center for Health ResearchDiabetes Research in Children Network (DirecNet) Study Group
- Contributors
- Michael J Tansey (Contributor) - University of Iowa, Stead Family Department of Pediatrics
- Resource Type
- Journal article
- Publication Details
- Pediatric diabetes, Vol.12(8), pp.690-695
- Publisher
- Wiley
- DOI
- 10.1111/j.1399-5448.2011.00764.x
- PMID
- 21496193
- PMCID
- PMC3193556
- ISSN
- 1399-543X
- eISSN
- 1399-5448
- Number of pages
- 6
- Grant note
- U10HD041919 / EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) HD041919-01; HD041915-01; HD041890; HD041918-01; HD041908-01; HD041906-01 / NIH/ NICHD; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) M01RR000069 / NATIONAL CENTER FOR RESEARCH RESOURCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) M01 RR00069; RR00059; RR 06022; RR00070-41 / GCRC; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR)
- Language
- English
- Date published
- 12/01/2011
- Academic Unit
- Endocrinology and Diabetes; Stead Family Department of Pediatrics; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9984354157602771
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