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The isolation and partial characterization of stable H2O2-resistant variants of Chinese hamster fibroblasts
Journal article   Peer reviewed

The isolation and partial characterization of stable H2O2-resistant variants of Chinese hamster fibroblasts

D R Spitz, G C Li, M L McCormick, Y Sun and L W Oberley
Basic life sciences, Vol.49, pp.549-552
01/01/1988
DOI: 10.1007/978-1-4684-5568-7_86
PMID: 3250510

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Abstract

Several groups have reported that bacteria exposed to H2O2 are capable of adapting to H2O2-mediated cytotoxicity.1–3 The adaptation is accompanied by a shift in relative rates of protein synthesis, increased antioxidant enzymatic activity, and increased resistance to other oxidizing agents and radiation.1–4 This adaptation phenomenon has been suggested to be a general response to oxidative stress common to all bacteria

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