Journal article
The long‐term efficacy of nucleos(t)ide analog plus a year of low‐dose HBIG to prevent HBV recurrence post‐liver transplantation
Clinical transplantation, Vol.26(5), pp.E561-E569
09/2012
DOI: 10.1111/ctr.12022
PMID: 23061767
Abstract
Hepatitis B immunoglobulin (HBIG), given in combination with nucleos(t)ide therapy, has reduced the rate of recurrent hepatitis B virus (HBV) following liver transplantation (LT), although the most effective protocol is unknown. We have retrospectively evaluated the use of long‐term nucleos(t)ide analog in combination with one yr of low‐dose HBIG. One hundred and fifty‐two adults with HBV‐related liver disease underwent LT in our center from January 1999 to August 2009; of these, 132 patients who received one yr of HBIG combined with long‐term nucleos(t)ide analogs (largely on lamivudine [LAM] alone, n = 97) afterward were included for the purposes of this study. Median follow‐up post‐transplantation was 1752 d. Patient survival was 93.9%, 86.9% and 84.1% at 1, 5, and 10 yr, respectively; none of the 17 deceased patients had recurrent HBV. HBV recurrence was observed in nine patients (all received LAM+HBIG), yielding recurrence rates of 2.3%, 5.1%, and 8.6% at 1, 3, and 5/10 yr, respectively. All recurrences were successfully managed, usually with additional antiviral treatment. In conclusion, this study, with its long‐term follow‐up, demonstrates that short course of low‐dose HBIG (without anti‐HBs monitoring) combined with the use of long‐term nucleos(t)ide analog is effective and less cumbersome than many protocols in current use.
Details
- Title: Subtitle
- The long‐term efficacy of nucleos(t)ide analog plus a year of low‐dose HBIG to prevent HBV recurrence post‐liver transplantation
- Creators
- Tomohiro Tanaka - University of TorontoAli Benmousa - University of TorontoMax Marquez - University of TorontoGeorge Therapondos - University of TorontoEberhard L Renner - University of TorontoLeslie B Lilly - University of Toronto
- Resource Type
- Journal article
- Publication Details
- Clinical transplantation, Vol.26(5), pp.E561-E569
- DOI
- 10.1111/ctr.12022
- PMID
- 23061767
- ISSN
- 0902-0063
- eISSN
- 1399-0012
- Number of pages
- 9
- Language
- English
- Date published
- 09/2012
- Academic Unit
- Gastroenterology and Hepatology; Internal Medicine
- Record Identifier
- 9984094541502771
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